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Alpha Ketoglutarate

A picture of the Alpha-ketoglutarate molecule
Alpha Ketoglutarate
Date Published: 09/07/2020
Date Modified: 06/23/2022
A picture of the Alpha-ketoglutarate molecule
 

AKG is an occurring endogenous intermediary metabolite and part of the Krebs cycle, which means that our own bodies create it.

AKG is a molecule involved in a number of metabolic and cellular pathways. It works as an energy donor, a precursor in amino acid production, and a cellular signaling molecule, and it is a regulator of epigenetic processes. It is a critical molecule in the Krebs cycle and regulates the overall speed of the citric acid cycle of an organism.

AKG also acts as a nitrogen scavenger, and it can prevent nitrogen overload and the build-up of excessive ammonia. It is also a key source of glutamate and glutamine, which stimulates protein synthesis and inhibits protein degradation in the muscles.

Additionally, it regulates the ten-eleven translocation (TET) enzymes, which are involved in DNA demethylation, and the Jumonji C domain containing lysine demethylases, which are the major histone demethylases. In this way, it is an important player in gene regulation and expression.

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