National University Singapore
We started out as a modest medical school with 23 students in 1905, founded by a determined group of businessmen led by Tan Jiak Kim, to serve the needs of the local community. Today, more than 100 years on, as Singapore’s flagship university, we continue to be in service of country and society. Learn more about our rich heritage and leaders of this institution.
Alpha-ketoglutarate, or AKG, is an energy donor molecule which is part of the Krebs cycle and involved in a number of metabolic and cellular pathways. Additionally, it regulates the ten-eleven translocation (TET) enzymes, which are involved in DNA demethylation, and thus is an important player in gene regulation and expression.