May 13, 2022
Professor João Pedro de Magalhães leads the Genomics of Ageing and Rejuvenation Lab at the Institute of Inflammation and Ageing in the University of Birmingham. He is also CSO of YouthBio Therapeutics, a US-based biotech company that develops rejuvenation gene therapies based on partial reprogramming by Yamanaka factors. Last year, he co-authored The hoverfly and...
May 12, 2022
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality. Why a cytomegalovirus? The human cytomegalovirus (CMV) is widely known as an endemic virus that, while usually...
May 11, 2022
Publishing in Nature Communications, Dr. Tom Yate, Dr. Neliesh J. Samani, and colleagues used data from approximately 400,000 people in the UK Biobank in order to examine the relationship between walking pace and telomere length. Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10...
May 10, 2022
Hosted by Ryan O'Shea, this episode of Lifespan News is on how plastic nanoparticles might lead to at least one hallmark of aging being accelerated. Script Studies show that everyday objects such as baby bottles and tea bags can release plastic particles into the environment and into our bodies. Now, new research shows the scale...
May 10, 2022
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In this paper, the authors argue that to tackle such a multifaced process as aging, it might be beneficial to target different molecular pathways using several...
May 10, 2022
In a pre-print paper, scientists have shown that treatment with NMN increases the survival and anti-cancer efficacy of CAR-T cells [1]. The problem with immunotherapy T cells are a central element of the adaptive immune system, and some of them can be cytotoxic: they have the ability to kill other cells. This lets us get...
