Chondroitin sulfate, widely known as chondroitin, has been shown to reduce mortality by a whopping 39% in a cohort of U.S. adults when taken with glucosamine [1]. For an equivalent mortality reduction from moderate exercise, the average person would have to walk one marathon per week

Alpha-lipoic acid (ALA) is a popular supplement and is often marketed as an antioxidant supplement. It serves multiple functions in the human body, and it may be useful against certain conditions. What is alpha-lipoic acid? ALA was first discovered in 1937. It began when Esmond Snell

Alpha-ketoglutarate (AKG) has been a popular sports supplement for a long time, but due to its roles in metabolism and aging, aging researchers have also taken an interest in it. What is alpha-ketoglutarate? AKG is a compound that is naturally produced in the body and is

Often touted as a solution for weak nails and hair growth, biotin is a common supplement. But do these claims stack up when it comes to the actual scientific evidence? Join us as we explore the research behind it. What is biotin? Biotin, also called vitamin

Naltrexone is a medication approved by the FDA to treat opioid addiction and alcohol dependence. This drug was developed in 1961 [1-2].  Naltrexone blocks the action of opioids at three key receptors that regulate a range of bodily functions. These include immune function, cell growth and

Urolithin A is a natural metabolite produced by gut bacteria that break down polyphenols in food. While there has been a significant amount of interest and hype around urolithin A supplements, we take a look at the reality to see if it measures up. Life, longevity,

Ashwagandha: Benefits, Uses, and Side Effects Ashwagandha supplements have become popular in recent years and are frequently touted as an important part of healthy lifestyles. Here is what the science says about this supplement. A supplement rooted in traditional medicine Ashwagandha, also known as winter cherry,

Pterostilbene is a popular supplement, especially within the longevity community. Perhaps most associated with blueberries which contain this substance, we take a look at its potential benefits. What is Pterostilbene? Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally occurring polyphenol, a type of molecule that occurs in plants. Langcake

Found in grapefruit, spermidine is one of the more interesting polyamines. Some research suggests that spermidine may slow down aging and promote healthy longevity. What is spermidine? Spermidine is a polyamine, meaning that it has two or more primary amino groups. It is naturally occurring and

Resveratrol is a popular supplement especially in the longevity community. There are numerous supplement companies touting it in adverts for weight loss and longevity. But do these promises really stack up?  What is Resveratrol? Resveratrol is a naturally occurring polyphenol. These are compounds found in plants

Berberine is a popular supplement in the longevity community that is often said to be similar to metformin. We take a look at the research behind this interesting naturally occuring compound. What is berberine? Berberine is an ammonium salt from the protoberberine group of benzylisoquinoline alkaloids.

NMN: Benefits, Uses, And Side Effects NMN is a naturally occurring molecule and a popular dietary supplement marketed as a NAD+ booster. What is NMN? Nicotinamide mononucleotide (NMN) is a naturally occurring molecule present in all species. On the molecular level, it is a ribonucleotide, a

This active ingredient in chamomile tea has traditionally been used to ease anxiety and reduce stress. There have been multiple scientific studies on this traditional use and several studies related to cellular aging. What is apigenin? Apigenin is a very common and widely distributed flavonoid in

Niacin is a widely used dietary supplement with a long research history and several tricks up its sleeve. Recent human trials have shed new light on its possible role in addressing mitochondrial dysfunction and aging. What is niacin? Niacin (Vitamin B3) is a water-soluble vitamin discovered

Found in many fruits and vegetables, quercetin is a natural antioxidant and popular dietary supplement that may have some potential against aging. What is quercetin? Quercetin is an evolutionarily conserved natural flavonoid, which makes it part of a large family of water-soluble plant compounds. Although quercetin