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Pearl: Participatory Evaluation of Aging with Rapamycin for Longevity

The first large-scale placebo-controlled clinical trial to determine the effects of Rapamycin on human longevity.

By Dr. Sajad Zalzala

Funding Successful. This project reached its goal before June 17, 2021.

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  • $182,838

    Pledged of $75,000 Goal

  • 409

    Backers

  • 243% Funded

    campaign complete

Campaign  Completed

Flexible Funding: All funds this campaign raises will be collected.

Launched: May 17, 2021
Funding Ends: June 17, 2021
Decentralized

PEARL Rapamycin Lifespan Campaign Banner: Rapamycin

A Groundbreaking Clinical Trial

The medicine Rapamycin has been shown to extend the healthspan of all organisms it has been tested on – mice, worms, yeast – for decades, and yet to date there has been no trial to sufficiently demonstrate safety and proper dosing for this purpose in humans. It is now time for this to change.

With your help, we will be conducting a large clinical trial named Participatory Evaluation (of) Aging (with) Rapamycin (for) Longevity Study, or PEARL, to find out. This will be the first study to see if Rapamycin works as well in humans as it does in mice (for longevity).

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Rapamycin was the first molecule proven to extend the lifespan of a mammal/mouse, even when given late in life (Harrison, D., Strong, R., Sharp, Z. et al. 2009). It also has the potential to treat aging related diseases (Blagosklonny, 2019) such as Alzheimer’s (Spilman P. et al. 2010) or heart disease, and not to mention, boost our immune system as well (Mannick JB. et al. 2014). It is by far the most studied longevity intervention after Calorie Restriction (CR).

Rapamycin works through the mTOR signaling pathway (Kennedy and Dudley 2016), one of the master regulators of cell metabolism and a key controller of autophagy (recycling in cells). Basically, it tells our cells to switch from growth to repair, and to clean out all the garbage. Not only that, but the quality of the proteins our cells produce increases, which means that there is less garbage in the first place. What all this amounts to is improved health and lengthened life for worms, flies and mice – now it’s our turn!

The PEARL trial will follow up to 200 participants over 12 months testing four different Rapamycin dosing regimens. It will be double-blind, randomized, placebo-controlled and registered with clinicaltrials.gov. The principal investigator is Dr. James P Watson at UCLA, who was also a PI for the famous TRIIM trial. To ensure safety the participants’ blood will be regularly monitored and side effects noted.

How Will We Know If It’s Working?

A battery of tests and measurements will be taken, both after 6 and 12 months. These will include autonomic health tests, blood tests, body composition tests, fecal microbiome testing, immune and inflammation health tests, methylation age clock testing and skeletal muscle tests.

With your help we will find out if and how well Rapamycin works to combat human aging. And, armed with a positive result, we will finally be able to help slow down onset of age related damage for you and those who you love and care about.

PEARL Rapamycin Lifespan Campaign Banner: Protocol

Interested patients will be screened for eligibility using AgelessRx‘s telemedicine platform. Eligible patients include those aged 50-85 of any sex or ethnicity, in relatively good health, and with only well-managed, clinically stable chronic diseases.

Once entered into the trial, the 200 patients will be divided into four dosing arms:

1. 2.5mg Rapamycin 3 times a week
2. 5mg Rapamycin once a week
3. 5mg Rapamycin twice a week
4. 10mg Rapamycin once a week

And a placebo control arm – vital for both scientific credibility and statistical analysis. We have carefully selected these dosing regimens, allowing for recovery each week and with the total dose would not exceeding the regular dose of Rapamycin used in renal transplant patients (current FDA-approved regimen).

The safety of the participants is of paramount importance, so, apart from watching out for any side effects, their blood will be monitored by looking at CBC, electrolytes, lipids, liver and renal function.

The following tests will be conducted for evaluating efficacy:

1. Autonomic health tests – including baseline (am) heart rate and baseline (am) heart rate variability testing.
2. Blood tests – Standard measures of risk of age-associated diseases (glucoregulatory markers, lipids), and markers of inflammation.
3. Body composition testing with DXA scans – measuring bone density as well as visceral fat content.
4. Fecal Microbiome testing.
5. Immune Health Tests – including CD4/CD8 ratio, CMV IgG, TNFɑ, hsCRP, and IL-6.
6. Methylation age – clock testing (e.g. Horvath clock, GrimAge).
7. Skeletal muscle tests – including lean body mass on DXA scan.
8. Physiological data – wearable devices (steps, HRV, etc).

The results of the trial will be published in an open access peer reviewed scientific journal.
In addition the data generated in the trial will be made available to any party.

PEARL Rapamycin Lifespan Campaign Banner: Budget

PEARL_Budget_PieChart

The most significant parts of our budget reflect the costs of performing of tests described in the PEARL protocol above — lab tests such as metabolic panels and insulin level analysis, and other tests such as microbiome and epigenetic clock biomarker testing — with the the remainder being allocated to sourcing the required amounts of Rapamycin and trial administration. While we’ve been able to mitigate costs thanks to the generous collaboration of Dr. Mikhail Blagosklonny at Roswell Park Comprehensive Cancer Center, James Clement at Better Humans, Adam Kadela at DexaFit, TruDiagnostic, GERO.ai, Mayo Clinic Translational Geroscience Network, Young.ai, and many others, it is still prohibitively expensive to run such a study with 200 participants. It is only thanks to the additional support of people like you that we will together be able to launch this trial, and answer key questions about Rapamycin’s efficacy to combat aging in humans.

PEARL Rapamycin Lifespan Campaign Banner: Goals

$75,000 — Initial Goal
Reaching our initial campaign goal will enable us to launch the PEARL trial to examine the healthspan extending effects of Rapamycin in humans. These funds, together with the generous support of our collaborators, will allow us to enroll 200 participants in this important study and run a battery of tests at the 6 month and 12 month mark: including autonomic health tests, blood tests, immune health tests, and skeletal muscle tests, along with more specialized testing at the 12 month mark: including microbiome testing, body composition testing via DXA scans, and methylation age testing with epigenetic markers such as the Horvath clock and GrimAge.
Estimated study duration: ~12 months.		 PEARL Goals - Initial Goal - PEARL Trial Launch
$120,000 — Stretch Goal 1
Attaining our first stretch goal will allow us to perform our entire battery of tests – including the specialized microbiome testing, body composition testing via DXA scans, and methylation age testing with epigenetic markers such as the Horvath clock and GrimAge — at the 6 month mark instead of only at the 12 month mark. Not only will this give us additional data points for longitudinal analysis, but will also be helpful in determining the minimal period of time Rapamycin dosing is required to see meaningful changes. All donors to this campaign at the $25 level or higher will be able to share in this process of discovery, seeing this data as soon as it becomes available.
Estimated study duration: same as initial goal.		 PEARL Goals - Stretch Goal 1 - Additional Testing
$165,000 — Stretch Goal 2
Reaching our final stretch goal will allow us to perform an entirely new set of proteomics testing at both the 6 month and 12 month mark. This is important because protein biomarkers can provide valuable insights into age related changes (Johnson A. et al. 2020) as well provide a comprehensive picture of chronic inflammation (Furman D. et al. 2019), a driving force behind age-related deterioration – “inflamm-aging”. It will also allow us to study the effect on proteins associated with immune system pathways, which is particularly important given Rapamycin’s known impact on immune system function. Including these tests within PEARL will therefore allow us collectively to gain the maximum amount of information we can regarding both the efficacy and safety of Rapamycin dosing regimens.
Estimated study duration:  same as initial goal.		 PEARL Goals - Stretch Goal 2 - Proteomics Testing
What Happens Next?

This first trial/phase is just the start.

It will be followed by a second trial/phase which will follow a larger number of participants over a longer period of time using the most effective dosing regime from the first trial/phase. It will also incorporate combinations with additional longevity drugs such as Metformin to assess any synergy with Rapamycin.

Furthermore, if this low cost and philanthropy funded trial succeeds, it will enable other longevity interventions to be tested – from generic drugs, to stem cell-based therapies, and beyond. Eventually, this will lead to the roll out of a wider variety of longevity interventions to the general public.

With your help, we can help transform the health of millions.

Thank you for your support!

PEARL Rapamycin Lifespan Campaign Banner: Team

Sajad Zalzala, M.D.
Co-Founder and Chief Medical Officer of AgelessRx
PEARL Rapamycin Lifespan Campaign Team: Sajad ZalzalaDr. Sajad Zalzala is the Co-Founder and Chief Medical Officer of AgelessRx. He combines the unique qualities of an experienced doctor passionate about disease prevention and longevity with the strategic vision and skills of a serial entrepreneur. Sajad has been passionate about slowing and reversing age-related diseases for 20 years. Sajad is one of the rare MD’s personally licensed in all 50 States, as well as Washington D.C. and Ontario. He has extensive experience working with startup companies in the telemedicine/telehealth field and has been an advisor to multiple successful healthcare startups, including Pill Club, Jack Health, forHims.
James Watson, Ph.D.
Principal Investigator of PEARL Trial
PEARL Rapamycin Lifespan Campaign Team: James WatsonDr. Watson is a board-certified Physician and co-founder of University Stem Cell Center in Santa Monica, California, where he conducted two of the first IRB-approved Phase I/II clinical trials in the US of autologous fat-derived stem cells for cosmetic and reconstructive surgery. More recently, he has successfully completed two small clinical trials in anti-aging therapies, one utilizing Rapamycin and another utilizing a triple cocktail of drugs and supplements that were shown to reverse epigenetic age in immune cells. He co-founded a biotech company, Biostrux, designed to commercialize “point-of-care”, adipose-derived stem cells with a bioresorbable scaffold to do “in situ” tissue engineering with autologous stem cells, work for which he has obtained three grants from the DOD and NIH. He has authored or co-authored over 30 scientific articles and book chapters, and co-authors an online blog on aging called “AGINGSCIENCES™, Anti-Aging Firewalls™” that has 85,000 regular readers worldwide. He speaks English and Thai, having grown up in Bangkok and Phuket for the first 12 years of his life.
Anar Isman, CFA
Co-Founder and CEO of AgelessRX
PEARL Rapamycin Lifespan Campaign Team: Anar IsmanAnar is Co-founder and CEO of AgelessRx. He is passionate about advancing the science of overcoming the negative effects of aging and giving everyone convenient and affordable access to the latest technologies. He has played an instrumental role in organizing the PEARL trial and establishing relationships with all collaborating partners. His hope is that this project will bring us one step closer to having a panel of “longevity” biomarkers as well as open the door for more citizen-based and philanthropy funded trials.

PEARL Rapamycin Lifespan Campaign Banner: Rewards
PEARL Rapamycin Lifespan Campaign Reward: Thank You
PEARL Rapamycin Lifespan Campaign Reward: Online Data
PEARL Rapamycin Lifespan Campaign Reward: Sticker Pride Pack
PEARL Rapamycin Lifespan Campaign Reward: T-Shirt
PEARL Rapamycin Lifespan Campaign Reward: Pride Pack Combo
PEARL Rapamycin Lifespan Campaign Reward: Growing Young Book by Sergey Young
PEARL Rapamycin Lifespan Campaign Reward: Book Shirt Pride Combo
PEARL Rapamycin Lifespan Campaign Reward: Lab Coat
PEARL Rapamycin Lifespan Campaign Reward: Video Call
PEARL Rapamycin Lifespan Campaign Reward: Elena Milova Painting
PEARL Rapamycin Lifespan Campaign Reward: Testing Panel
PEARL Rapamycin Lifespan Campaign Reward: Mikhail Blagosklonny Talk
PEARL Rapamycin Lifespan Campaign Reward: Team Dinner
PEARL Rapamycin Lifespan Campaign Reward: Paper Acknowledgement
Disclaimer: Contributing to this campaign does not entitle contributor to be enrolled in the trial

Contributions to this campaign are received as donations to LEAF via Fiscal Sponsorship.

Rewards

Posted on 07/04/2021 by Steve Hill

Thank you once gain for supporting the PEARL campaign!

This is just a quick update to let you know that we engaging with our reward fulfilment manager and will be arranging the production and shipping of the T-shirts, buttons, and other physical rewards in the coming weeks.

For the non-physical rewards such as Q&A with the team we will be following up with you soon. We will keep you updated as things develop.

Thank you, and all of you in the USA have a Happy 4th of July!


17 Comments

  1. Reply
    Dr. Desmond Menon

    Hi there,
    This sounds like an interesting clinical trial.
    I might have interested funders for your project.
    Please provide more information on your clinical study, stage, and company along with how we can be involved.
    Kind regards,

  2. Reply
    Moya

    Thank you for the great work, I hope you will reach the funding goal very soon! :)

    I was wondering about the “Receive all tests that make up the PEARL protocol” reward – are these tests simple to do at home, or would I need to find some medical person who is willing to do them with me?
    And do these tests ship worldwide (in my case to Europe), or are there problems due to interesting chemicals in them?

    • Reply
      Anar

      Hi Moya,
      Thanks for your question and interest.
      The tests are NOT do at home tests. They will be collected by specialized phlebotomists who would come to participants residences, collect blood and send it to the blood bank.

      We currently don’t have a plan for offering this service to folks in Europe. I would need to research this to see
      1. if we can have a phlebotomist perform blood draw in Europe
      2. if they can ship blood to blood bank in US in an appropriately timely manner.

      I will try to find an answer as soon as possible but in the meantime, I am afraid that the answer is that it is not available in Europe.

      Anar

      • Reply
        Moya

        Thank you very much – it would have been silly to go for this particular reward and to then not be able to make use of it.

        I think I will just go for a different backing amount then – no problem at all. :)

  3. Reply
    joker Karlsson

    I would love to be one of the 200 test subject. How do i volunteer?

    • Reply
      Anar

      Thanks for your question.
      This is the first of potentially many trials. If this trial’s unique philanthropy- and citizen- funded method ends up working successfully it will open the door for other trials; D/Q being one of them.

      • Reply
        Neil Christensen

        Awesome! I look forward to supporting many more! I agree senolytics is a great target. I would also love to see an NBE human clinical trial, probably with recombinant human serum albumin, in the near term.

  5. Reply
    louisbreone

    Does the PEARL trial have the same purpose as the TAME trial ?

    That is , provide strong evidence that rapamycin can , like metformin in the TAME trial , target aging and thus prevent most age-related diseases?

    And in the long term, could rapamycin be approved for aging when there is sufficient evidence , as the TAME trial with metformin hopes ?

  6. Reply
    Art

    Main or only problem is to find the “correct” individual dosage ! A very tricky difficulty. Learn from resTORbio´s failure

  7. Reply
    Moya

    As we are getting close to reaching the first Stretch Goal I was wondering:
    The text says that the first Stretch Goal is at $120,000, but the little progress bar on the right says that the first Stretch Goal is at $125,000.
    So which one is it? :)

  8. Reply
    Steven

    Now that you’ve hit the 2nd stretch goal, can you comment on what will be done with additional funds beyond the $150k?

    • Reply
      anar

      Hi Steven,
      Thanks for your question.

      The additional funds will allow us to measure additional biomarkers.
      The base case budget is for measuring:
      IGF-1 (fasting)
      Lipid Panel, Standard
      TNFa
      IL-6
      VLDL
      Comprehensive Metabolic Panel*
      HgAC1
      Uric Acid
      CBC & DIFF
      CD4/CD8
      CMV IgG titers
      hs-CRP
      Vitamin D, 25-OH Total (VIT D,25-OH,TOTAL,IA)
      sirolimus level

      Additional funds will be used to measure additional biomarkers, in particular:
      Cystatin C
      GDF 15
      Adiponectin
      Leptin

      I hope this answers your question.

  9. Reply
    Anar

    Hi Steven,
    Thanks for your question.

    The additional funds will allow us to measure additional biomarkers.
    The base case budget is for measuring:
    IGF-1 (fasting)
    Lipid Panel, Standard
    TNFa
    IL-6
    VLDL
    Comprehensive Metabolic Panel*
    HgAC1
    Uric Acid
    CBC & DIFF
    CD4/CD8
    CMV IgG titers
    hs-CRP
    Vitamin D, 25-OH Total (VIT D,25-OH,TOTAL,IA)
    sirolimus level

    Additional funds will be used to measure additional biomarkers, in particular:
    Cystatin C
    GDF 15
    Adiponectin
    Leptin

    I hope this answers your question.

  10. Reply
    Chuong Nguyen

    Great initiative and community involvement! Come here after Prof David Sinclair’s Tweet. @Anar thank you for sharing more information. I assume this research recruits people in US only.

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    $750.00
  • Micah Zoltu
    Micah Zoltu
    $10,000.00
  • Vitalik Buterin
    Vitalik Buterin
    $10,000.00
  • Yoel Kelman
    Yoel Kelman
    $100.00
  • SurvivalBias
    Aleksandr Petukhov
    $100.00
  • Viktor Glazunov
    Viktor Glazunov
    $25.00
  • Avatar
    Anonymous
    $200.00
  • Adam Balazs
    Adam Balazs
    $25.00
  • Mathieu Cloutier
    Mat Cloutier
    $150.00
  • Emiel van der Horst
    Emiel van der Horst
    $10.00
  • Thimma Reddi
    Thimma Reddi
    $150.00
  • Richard Parton
    Richard Parton
    $10.00
  • Benjamin
    Benjamin Yeung
    $50.00
  • Simon Tost
    Simon Tost
    $175.00
  • William Trevino
    William Trevino
    $25.00
  • Balázs Suhajda
    Balazs Suhajda
    $30.00
  • David Hedenrud
    David Hedenrud
    $25.00
  • Avatar
    Anonymous
    $25.00
  • Mike Barraclough
    Mike Barraclough
    $75.00
  • Fabian Schrötter
    Fabian Schrötter
    $100.00
  • Tyler Hruby
    Tyler Hruby
    $10.00
  • Itzhak Dershowitz
    Itzhak Dershowitz
    $10.00
  • Avatar
    Anonymous
    $100.00
  • Gennady Stolyarov II
    Gennady Stolyarov
    $150.00
  • Avatar
    Anonymous
    $25.00
  • Linda Backman
    Linda Backman
    $50.00
  • Leif
    Emil Edman Hellberg
    $20.00
  • Avatar
    Anonymous
    $25.00
  • Simon Holk
    Simon Holk
    $10.00
  • Ray Melissa
    Ray Melissa
    $100.00
  • Brad Armstrong
    Brad Armstrong
    $4,500.00
  • Brad Armstrong
    Brad Armstrong
    $10,000.00
  • Avatar
    Anonymous
    $10,000.00
  • David Zhang
    david zhang
    $25.00
  • Richard Ludka
    Richard Ludka
    $10.00
  • Avatar
    Anonymous
    $5,000.00
  • Michael
    MICHAEL RAE
    $100.00
  • Avatar
    Anonymous
    $25.00
  • Jake Jones
    Jake Jones
    $10.00
  • Avatar
    Anonymous
    $150.00
  • Kevin Kin
    Kevin Kin
    $25.00
  • Konstantin Sinkevich
    Konstantin Sinkevich
    $200.00
  • Bertrand Bazire
    Bertrand Bazire
    $150.00
  • Louis Gerrue
    Louis Gerrue
    $25.00
  • Leroy Arellano
    Leroy Arellano
    $25.00
  • Austin Henderson
    Austin Henderson
    $25.00
  • Lars Claussen
    Lars Claussen
    $75.00
  • Benjamin Santiago
    Benjamin Santiago
    $25.00
  • Cillian Jefferson
    Keenan Kornegay
    $25.00
  • Fabian Schrötter
    Fabian Schrötter
    $225.00
  • Avatar
    Anonymous
    $75.00
  • kyle litwin
    kyle litwin
    $10.00
  • Liam Iles
    Liam Iles
    $25.00
  • Koensgen Benjamin
    Koensgen Benjamin
    $10.00
  • Avatar
    Anonymous
    $100.00
  • Avatar
    Anonymous
    $50.00
  • lhitch
    Lance Hitchings
    $25.00
  • Eduard Boiko
    Eduard Boiko
    $10.00
  • Rasmus Rasch
    Rasmus Rasch
    $150.00
  • Konstantin Sinkevich
    Konstantin Sinkevich
    $25.00
  • Avatar
    Anonymous
    $15,000.00
  • Avatar
    Anonymous
    $100.00
  • Avatar
    Anonymous
    $25.00
  • Fabian Schrötter
    Fabian Schrötter
    $75.00
  • nicholas-singh
    Nicholas Singh
    $25.00
  • Linda Hannus
    Linda Hannus
    $10.00
  • Gregers Krabbe
    Gregers Krabbe
    $10.00
  • Michal Szymacha
    Michal Szymacha
    $225.00
  • Ryan Kraudel
    Ryan Kraudel
    $25.00
  • Steve Randolph
    Steve Randolph
    $20.00
  • David Kelly
    David Kelly
    $50.00
  • Nathan Cheng
    Nathan Cheng
    $100.00
  • Avatar
    Anonymous
    $50.00
  • Jason Roeschley
    Jason Roeschley
    $25.00
  • Stephen Malina
    Stephen Malina
    $25.00
  • William DeVore
    WILLIAM DEVORE
    $25.00
  • Avatar
    Anonymous
    $10.00
  • Matteo Durante
    Matteo Durante
    $100.00
  • Natalia & Tim Drohan
    Natalia & Tim Drohan
    $25.00
  • Mark Lambert
    Mark Lambert
    $25.00
  • Marc Bresenoff
    Marc Bresenoff
    $25.00
  • Avatar
    Anonymous
    $25.00
  • Time Haven
    Anthony Jennings
    $150.00
  • Breanna Deutsch
    Breanna Deutsch
    $25.00
  • Kyle Benkendorfer
    Kyle Benkendorfer
    $100.00
  • Kevin Bärudde
    Kevin Bärudde
    $10.00
  • Avatar
    Anonymous
    $35.00
  • Avatar
    Anonymous
    $50.00
  • MTSowbug
    Michael Todhunter
    $100.00
  • Michael Wester
    MICHAEL WESTER
    $50.00
  • Avatar
    Anonymous
    $150.00
  • Curry Taylor
    Curry Taylor
    $150.00
  • Avatar
    Anonymous
    $5.00
  • Albert Nigrin
    Albert Nigrin
    $100.00
  • neil Vasilakes
    Neil Vasilakes
    $25.00
  • Robert Arbetter
    Robert Arbetter
    $25.00
  • Tom Moya Schau
    Tom Moya Schau
    $4,000.00
  • robert jenner
    Robert Jenner
    $50.00
  • Alexander Shmidt
    Oleksandr Shmidt
    $10.00
  • Miguel Lopes
    Miguel Lopes
    $75.00
  • Dustin D. Trammell
    Dustin D. Trammell
    $100.00
  • Avatar
    Anonymous
    $50.00
  • Silvia Prieto
    Silvia Prieto
    $25.00
  • James Schultz
    James Schultz
    $1,000.00
  • Dan Healy
    Dan Healy
    $25.00
  • Avatar
    Anonymous
    $350.00
  • Moncomble Florian
    Moncomble Florian
    $25.00
  • Avatar
    Anonymous
    $25,000.00
  • balint
    Balint Erdi
    $25.00
  • Jason Brisbois
    Jason Brisbois
    $100.00
  • Dan Hightower
    Dan Hightower
    $25.00
  • nick mitsakis
    Nick Mitsakis
    $20.00
  • Laurent Saunier
    Laurent Saunier
    $100.00
  • Dwayne DeBardelaben
    Dwayne DeBardelaben
    $150.00
  • Linus Petersson
    Linus Petersson
    $10.00
  • Avatar
    Anonymous
    $25.00
  • Shlomo Small
    Shlomo Small
    $10.00
  • Jordan LAURENT
    Jordan Laurent
    $10.00
  • Sofya Nikolaeva
    Sofya Nikolaeva
    $25.00
  • Apeiron
    Duley Crabbe
    $10.00
  • Chris McAulay
    Chris Mcaulay
    $10.00
  • dim
    Dmitry Sadovnikov
    $25.00
  • Mike Bosse
    Mike Bosse
    $150.00
  • Josh Clemente
    Josh Clemente
    $100.00
  • jrice1848
    James Rice
    $100.00
  • Shannon Vyff
    Shannon Vyff
    $10.00
  • Avatar
    Anonymous
    $40.00
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    Anonymous
    $25.00
  • Eric Schulke
    Eric Schulke
    $10.00
  • jdavids
    John Davids
    $10.00
  • Áron Ecsedy
    Áron Ecsedy
    $25.00
  • Richard Smith
    Richard Smith
    $10.00
  • abritrn
    Amy Britton
    $25.00
  • tim_nevelsk
    Tim Padvitski
    $10.00
  • Andreas Kammerer
    Andreas Kammerer
    $150.00
  • ilkka.liukas
    Ilkka Liukas
    $150.00
  • Sam Holmes
    Sam Holmes
    $150.00
  • Jeffrey Rush
    Jeffrey Rush
    $100.00
  • ancerasdiybio
    Jamie Knight
    $25.00
  • Colorow
    Katherine Dodds
    $25.00
  • Richard Sapp
    Richard Sapp
    $25.00
  • Mahdi Daraei
    Mahdi Daraei
    $10.00
  • Alexander Kiskin
    Alexander Kiskin
    $50.00
  • james kelly
    james kelly
    $75.00
  • Adam Hruby
    Adam Hruby
    $25.00
  • Michael Beasley
    Michael Beasley
    $75.00
  • Avatar
    Anonymous
    $25.00
  • kymconnolly
    Kym Connolly
    $25.00
  • Avatar
    Anonymous
    $100.00
  • Neil Kauffman
    Neil Kauffman
    $150.00
  • Fabio69
    Fabio Quirici
    $50.00
  • Olivia White
    Olivia White
    $50.00
  • Ivan Karlovich
    Ivan Karlovich
    $10.00
  • Karolina Siedler
    Karolina Siedler
    $1.00
  • Exo
    Viktoriya Perepletkina
    $25.00
  • Avatar
    Anonymous
    $20.00
  • Avatar
    Anonymous
    $10.00
  • Avatar
    Anonymous
    $750.00
  • Jan Renter
    Jan Renter
    $25.00
  • Joe Franks
    Joe Franks
    $10.00
  • thisishal
    Hal Tepfer
    $75.00
  • Fred Perry
    Fred Perry
    $10.00
  • Gerardo Vazquez de Miguel
    Gerardo Vazquez de Miguel
    $10.00
  • Ferdinando Randisi
    Ferdinando Randisi
    $150.00
  • Ariel Schön
    Ariel Schön
    $75.00
  • Avatar
    Anonymous
    $100.00
  • Edward Warburton
    Edward Warburton
    $25.00
  • Daniel Smith
    Daniel Smith
    $100.00
  • Robert Adams
    Robert Adams
    $25.00
  • Andy Jones
    Andy Jones
    $225.00
  • orenmilman
    Oren Milman
    $150.00
  • Avatar
    Anonymous
    $75.00
  • Robert Reyes
    Robert Reyes
    $50.00
  • Avatar
    Anonymous
    $10.00
  • howie story
    Howard Story
    $10.00
  • Christopher Alvarez
    Christopher Alvarez
    $150.00
  • Michael Sherman
    Michael Sherman
    $250.00
  • SurvivalBias
    Aleksandr Petukhov
    $100.00
  • Avatar
    Anonymous
    $50.00
  • Fred Bell
    Fred Bell
    $75.00
  • Gary Hirst
    Gary Hirst
    $150.00
  • Shane Tolmie
    Shane Tolmie
    $200.00
  • Danny Peeters
    Danny Peeters
    $25.00
  • Transhuman Tees
    Transhuman Tees
    $10.00
  • Steve Delgrange
    Steve Delgrange
    $25.00
  • Avatar
    Anonymous
    $10,000.00
  • Louie Helm
    Louis Helm
    $10.00
  • Peter Hall
    Peter Hall
    $10.00
  • Aleksandr Popov
    Aleksandr Popov
    $75.00
  • Whit Miller
    Whit Miller
    $25.00
  • Ernst Van Graan
    Ernst Van Graan
    $10.00
  • john leahy
    john leahy
    $10.00
  • Christopher Ottesen
    Christopher Ottesen
    $10.00
  • Abdul Ibrahim
    Abdul Ibrahim
    $10.00
  • jim plante
    jim plante
    $25.00
  • forever robin
    Robin Rose
    $10.00
  • Bmjacobs
    Bob Jacobs
    $15.00
  • robtex7
    Robert Rangel
    $25.00
  • Avatar
    Anonymous
    $25.00
  • Janis Elsts
    Janis Elsts
    $100.00
  • Didier Coeurnelle
    Didier Coeurnelle
    $25.00
  • Avatar
    Anonymous
    $150.00
  • Ricardh01
    Richard Harvey
    $25.00
  • Chirag Pattni
    Chirag Pattni
    $10.00
  • Ben Wu
    Ben Wu
    $25.00
  • Adam McDonald
    Adam McDonald
    $25.00
  • Micah Zoltu
    Micah Zoltu
    $10,000.00
  • Christopher van Buren
    Dimitriou Frideriki
    $150.00
  • Robert James Powles
    Robert Powles
    $10.00
  • Avatar
    Anonymous
    $10.00
  • Alen German
    Alen German
    $100.00
  • ARTUR DAVIDYAN
    Artur Davidian
    $10.00
  • YOUSIF ALOWLH
    A R
    $25.00
  • Ilya Borisov
    Ilya Borisov
    $10.00
  • peter svensson
    Peter Svensson
    $30.00
  • Corbin
    Corbin S.
    $150.00
  • Nealicus
    Jake Mabey
    $150.00
  • Joseph Anthony
    Joseph Anthony
    $50.00
  • GeorgeDavis
    GEORGE DAVIS
    $10.00
  • joshua farahzad
    Joshua Farahzad
    $100.00
  • Styn Labeeuw
    Styn Labeeuw
    $10.00
  • Vincent Weisser
    Vincent Weisser
    $10.00
  • Alex Gewecke
    Alex Gewecke
    $25.00
  • Avatar
    Anonymous
    $150.00
  • Balázs Suhajda
    Balazs Suhajda
    $25.00
  • Scott Slotterbeck
    Scott Slotterbeck
    $35.00
  • Avatar
    Anonymous
    $10.00
  • Richard A Sundvall
    Richard A Sundvall
    $1,000.00
  • Chris Linnell
    Chris Linnell
    $100.00
  • Neil
    Neil Christensen
    $75.00
  • Alfred Fulbright
    Alfred Fulbright
    $100.00
  • Matej Pankovcin
    Matej Pankovcin
    $150.00
  • David Rosenberg
    David Rosenberg
    $25.00
  • Avatar
    Anonymous
    $250.00
  • Avatar
    Anonymous
    $10.00
  • John D Gauchat
    John D Gauchat
    $25.00
  • Oliver Ward
    Oliver Ward
    $50.00
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    $75.00
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  • Pledge Without Reward

    43 Backers
  • Pledge $10
    Reward 1

    119 Backers

    WEBSITE THANK YOU PAGE — Your name listed on a special thank you page on our website; thanks for joining the cause! All higher donation reward levels will include this reward.

    Estimated delivery:
    Shortly after donation
  • Pledge $25
    Reward 2

    126 Backers

    $10 Pledge Reward + ONLINE EXPERIMENTAL DATA — Access to website displaying project data and quarterly updates on the project in progress. All higher donation reward levels will include this reward.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $50
    Reward 3

    14 Backers

    $25 Pledge Reward + PEARL PRIDE PACK — You will receive 3-inch PEARL and AgelessRX buttons and stickers for you to proudly display on your bag, laptop, or car. Show the world your support for this worthy cause!

    Estimated delivery:
    2 months after campaign completion
  • Pledge $75
    Reward 4

    21 Backers

    $25 Pledge Reward + PEARL T-SHIRT — Show your support for breakthrough longevity research with this custom designed T-Shirt representing the project! Your choice of either Turquoise or Black, each available in S, M, L, XL, XXL. + $10 for international shipping.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $100
    Reward 5

    31 Backers

    $25 Pledge Reward + PROJECT T-SHIRT + PRIDE PACK — Receive the PEARL Project T-Shirt ($75 pledge reward), the Buttons and Stickers Pride Pack ($50 pledge reward), and the online data access ($25 pledge reward) all together in a great combination! + $10 for international shipping.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $150
    Reward 6

    35 Backers

    $25 Pledge Reward + AUTOGRAPHED COPY OF "GROWING YOUNG" — Personalized autographed copy of the book "Growing Young" by Sergey Young, founder of the Longevity Vision Fund and sponsor of the Age Reversal XPRIZE. + $15 for international shipping.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $225
    Reward 7

    7 Backers

    $100 Pledge Reward + AUTOGRAPHED COPY OF "GROWING YOUNG" — Receive the PEARL Project T-Shirt, Pride Pack, and online data access + autographed copy of the book "Growing Young" by Sergey Young, all together. + $15 for international shipping.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $350
    Reward 8

    2 Backers
    Limit of 30 — 28 remaining

    $25 Pledge reward + LIMITED EDITION AGELESSRX LAB COAT — Support aging research and the PEARL project in ultimate style by wearing this limited edition lab coat, with AgelessRx logo. + $15 for international shipping.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $750
    Reward 9

    3 Backers
    Limit of 20 — 17 remaining

    $25 Pledge Reward + VIDEO Q & A WITH PEARL TEAM — Participate in a personal 30-minute video conference with Dr. Sajad Zalzala and Anar Isman of the PEARL team. Discuss aging research, ask questions, and hear the most exciting news about the ongoing project!

    Estimated delivery:
    Shortly after donation
  • Pledge $1,000
    Reward 10

    2 Backers
    Limit of 10 — 8 remaining

    $25 Pledge Reward + ORIGINAL ARTWORK BY ELENA MILOVA — A unique work of art by Lifespan.io COO Elena Milova. Be inspired with a choice of serene landscape or fierce dragon ouroboros. All paintings on canvas on a wooden frame 40x60cm, acrylics. + $50 for shipping.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $4,500
    Reward 11

    2 Backers

    $25 Pledge Reward + PEARL TESTING MATERIALS — Receive all tests that make up the PEARL protocol, as described on in this project campaign, so you can follow along with your own choice of interventions. Rapamycin not included.

    Estimated delivery:
    2 months after campaign completion
  • Pledge $5,000
    Reward 12

    1 Backer
    Limit of 5 — 4 remaining

    $25 Pledge Reward + VIDEO Q & A WITH DR. MIKHAIL BLAGOSKLONNY — Participate in a personal 30-minute video conference with Dr. Mikhail Blagosklonny, biogerontologist, rapmycin / TOR pioneer, and editor-in-chief of Aging: http://aging-us.com.

    Estimated delivery:
    Shortly after donation
  • Pledge $7,500
    Reward 13

    1 Backer
    Limit of 3 — 2 remaining

    $25 Pledge Reward + PRIVATE DINNER WITH PEARL TEAM — Meet Dr. Sajad Zalzala and Anar Isman of AgelessRx, a perfect opportunity to talk about the project, ask questions, and discuss the future of telemedicine and research aimed at overcoming the diseases of aging. Travel not included.

    Estimated delivery:
    3 months after campaign completion
  • Pledge $10,000
    Reward 14

    2 Backers
    All gone!

    $25 Pledge Reward + FORMAL ACKNOWLEDGEMENT + SIGNED FRAMED PROOF OF PAPER — You will receive a framed copy of a peer-reviewed scientific paper resulting from this work, with your name appearing in the acknowledgments section, thanking you for generously helping this important research and signed by the AgelessRx team.

    Estimated delivery:
    12 months after campaign completion