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Tag: iPSCs

Mitochondrion
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to...
Dividing cells
A team of researchers, including Michael West of AgeX Therapeutics, has authored a review paper that posits a fundamental difference between "immortal" germline cells and "mortal" somatic cells. The two types of cells This review paper, which cites 175 other papers, goes back throughout history, discussing the very earliest scientific theories of aging. It talks...
LifeXtenShow on cellular rejuvenation
In this episode of X10, Nicola explains a way to epigenetically reset cells using the OSKM Yamanaka factors, putting them back into a pluripotent stem cell state. These factors have also been experimentally shown to restore cells to youth in other ways, and it is also possible to carefully use these factors to make cells...
Piglet
The latest research published in the Journal of Tissue Engineering and Regenerative Medicine has reprogrammed pig fibroblast cells into neural progenitor cells.
Mouse eye
A group of researchers has succeeded in directly reprogramming fibroblast cells into photoreceptors and transplanting them into mice, which resulted in partial restoration of vision [1]. This achievement can potentially lead to the development of cheap and effective treatments for retinopathies such as age-related macular degeneration (AMD), the leading cause of vision loss in older...
Retina
Researchers from Johns Hopkins Medicine have successfully used stem cells to repair diabetic damage to retinal blood vessels. The researchers believe that their findings will advance regenerative approaches that seek to reverse conditions such as diabetic retinopathy and other eye diseases that lead to blindness. Induced pluripotent stem cells (iPSCs) have been around for well...