Γ—

Exporting a Longevity Mechanism Between Species

Join us for Journal Club August 2023

Share







The Journal Club is a monthly livestream hosted by Dr. Oliver Medvedik which covers the latest aging research papers.The Journal Club is a monthly livestream hosted by Dr. Oliver Medvedik which covers the latest aging research papers.

The Journal Club for August returns live to the Lifespan.io Facebook channel on September 5th at 12:00 Eastern hosted by Dr. Oliver Medvedik. This time we are taking a look at a paper where researchers have transfered a lifespan and healthspan boosting mechanism from the naked mole rat, a very long lived rodent, to mice. The paper includes researchers such as Vera Gorbunova, Steve Horvath, and Vadim Gladyshev and demonstrates that longevity is something that can be emulated from one species to another.

This study raises interesting questions and possibilities. Perhaps we can learn new tricks from species like the naked mole rat that do not age the same way we do.

Abstract Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and possibly to the longevity of the longest-lived rodent-the naked mole-rat1,2. To study whether the benefits of HMM-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHas2). nmrHas2 mice showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan. The transcriptome signature of nmrHas2 mice shifted towards that of longer-lived species. The most notable change observed in nmrHas2 mice was attenuated inflammation across multiple tissues. HMM-HA reduced inflammation through several pathways, including a direct immunoregulatory effect on immune cells, protection from oxidative stress and improved gut barrier function during ageing. These beneficial effects were conferred by HMM-HA and were not specific to the nmrHas2 gene. These findings demonstrate that the longevity mechanism that evolved in the naked mole-rat can be exported to other species, and open new paths for using HMM-HA to improve lifespan and healthspan.

Literature

Zhang, Z., Tian, X., Lu, J. Y., Boit, K., Ablaeva, J., Zakusilo, F. T., Emmrich, S., Firsanov, D., Rydkina, E., Biashad, S. A., Lu, Q., Tyshkovskiy, A., Gladyshev, V. N., Horvath, S., Seluanov, A., & Gorbunova, V. (2023). Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.Β Nature, 10.1038/s41586-023-06463-0. Advance online publication. https://doi.org/10.1038/s41586-023-06463-0
About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
No Comments
Write a comment:

*

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.