September 30, 2022
To understand human longevity, we need to put it into perspective. Are we relatively long-lived or short-lived creatures? After all, among all the plants and animals in nature, we find a vast variety of lifespans, from several hours to several millennia, and possibly even more. While humans are the most long-lived primates, our lifespan pales...
June 17, 2022
Naked mole rats are long-lived rodents famous for their resistance to cancer and sustained healthy lifespan. In a new study published in the Journal of Investigative Dermatology, researchers have shown that the skin of older members of this species is characterized by high expression of longevity-associated and tumor-suppressing genes [1]. Getting under the skin Skin...
May 05, 2022
A study published in Aging has shown that the skin of the naked mole rat retains nearly all of its physical and biochemical properties as these animals chronologically age, providing new insight into how and why these animals live so long. Wrinkly, but not like humans wrinkle With a wrinkly, largely hairless body, the naked...
April 15, 2022
In a study published in Nature, scientists have found an extremely strong correlation between somatic mutation rate and lifespan across several species, highlighting the importance of mutation burden for aging [1]. The question of why lifespan varies so vastly among species, including closely related ones, has always fascinated geroscientists. Studying exceptionally long-lived species might reveal...
February 03, 2022
A research paper published in Nature by Dr. Vadim Gladyshev and his team has investigated the epigenetic aging of the naked mole rat, an animal whose mortality rate does not appear to increase with age. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and...
July 30, 2020
The well-known resistance of naked mole rats to aging and aging-related effects is due at least in part to an unusual ability to clear away senescent cells. This suggests that senolytic drugs, which aim to do the same in humans, may prove a fruitful path to longevity. Naked mole rats live much longer than other...
