Tag: Steve Horvath

Dr. Steve Horvath hardly needs an introduction, so we will be brief: he is the inventor of the epigenetic clock and, currently, principal investigator at Altos Labs. We talked about the recent developments in this immensely important field, including pan-mammalian clocks, two-species clocks, and single-cell clocks, along with the challenges the field faces. You are...

A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of mice. Rapamycin before and after weaning In this placebo-controlled experiment, the researchers selected the UMHET3 strain of mice, as it is a crossbreed that does...

In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing clocks that measure biological age. We talked with Dr. Levine about her work, the impact that biological age clocks have had on the longevity field,...

In his talk at Ending Age-Related Diseases 2021, Steve Horvath discussed a cytosine-based, pan-mammalian epigenetic clock that works across a wide variety of species. He also discussed how several of the hallmarks of aging do not seem to have any effect on epigenetic alterations.  Script Hello, thank you for your interest. My name is...

A new study published in the Journals of Gerontology has shown that the epigenetic clock GrimAge is a strong predictor of the effects of aging, particularly all-cause mortality: the likelihood of dying from any cause. Did previous clocks use the wrong target? As the researchers explain, the first-generation epigenetic clocks of Drs. Horvath (who contributed...

Researchers have proposed a new epigenetic clock designed to measure subtle epigenetic changes in vitro [1]. They hope that their discovery will help to expedite the creation of new anti-aging drugs. Measuring biological age Aging research is all about the difference between chronological and biological age. The former is simply the passage of time, but...