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Tag: Steve Horvath

Steve Horvath at EARD2021
In his talk at Ending Age-Related Diseases 2021, Steve Horvath discussed a cytosine-based, pan-mammalian epigenetic clock that works across a wide variety of species. He also discussed how several of the hallmarks of aging do not seem to have any effect on epigenetic alterations.  Script Hello, thank you for your interest. My name is...
Steve Horvath at Ending Age-Related Diseases 2020
Dr. Steve Horvath is very well known in the field for his groundbreaking work on epigenetic clocks, which use one of the hallmarks of aging, epigenetic alterations, in order to calculate biological age. In his talk at Ending Age-Related Diseases 2020, he discussed how such clocks can be used to evaluate the effectiveness of rejuvenation...
Death clock
A new study published in the Journals of Gerontology has shown that the epigenetic clock GrimAge is a strong predictor of the effects of aging, particularly all-cause mortality: the likelihood of dying from any cause. Did previous clocks use the wrong target? As the researchers explain, the first-generation epigenetic clocks of Drs. Horvath (who contributed...
DNA clock
Researchers have proposed a new epigenetic clock designed to measure subtle epigenetic changes in vitro [1]. They hope that their discovery will help to expedite the creation of new anti-aging drugs. Measuring biological age Aging research is all about the difference between chronological and biological age. The former is simply the passage of time, but...
DNA clock
A team of researchers, including Drs. Vadim Gladyshev and Steve Horvath, recently published a review of DNA methylation aging clocks, which use biomarkers to determine the biological age of a person. Aging causes epigenetic alterations to occur, including changes to DNA methylation, histone modification, transcriptional alterations (variance in gene expression), and remodeling of chromatin (a...
Lab mouse
Today, we want to draw attention to a new study that shows how partial cellular reprogramming was able to reverse cellular aging and address age- and injury-induced blindness in mice. Epigenetic alterations One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are...