Search Results for: hallmarks of aging

Quercetin is a natural flavonoid, which makes it part of a large family of water-soluble plant compounds. Flavonoids are an important part of a healthy diet.
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Nicotinamide mononucleotide (NMN) is a precursor of the coenzyme NAD+, which serves critical functions in our cells. The decline of NAD+ with age is associated with the development of some age-related diseases.
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Whenever the topic of increasing human lifespan is discussed, the concern is sometimes raised that a longer life would mean a life spent frail and decrepit. This is sometimes known as the Tithonus error and shows a fundamental misunderstanding of the aims of rejuvenation biotechnology.
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Drs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed that cellular identity and aging could be reset with just four reprogramming factors, it causes cells to forget their functions and organs. However, exposure to reprogramming factors for just long enough can reverse the age of a cell without erasing its identity. This is the basis of partial cellular reprogramming.
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Metabolic syndrome drives many of the hallmarks of aging, and different hallmarks of aging drive metabolic syndrome in a vicious, accelerating cycle. Central obesity, high triglycerides, low HDL cholesterol, high blood pressure, and elevated fasting glucose comprise a cluster of metabolic disorders that increase the risk of cardiovascular disease and type 2 diabetes and define metabolic syndrome.
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It’s not uncommon, especially for outsiders of a given field, to use an inappropriate word to indicate a more complex concept than the word itself conveys, maybe because they think that the two are close enough or possibly because they just don’t see the difference. For this reason, it’s likely that each field has its own unspeakably profane word; in the field of rejuvenation biotechnology, that word is the dreaded I-word: immortality.
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Intermittent fasting (IF) is an eating pattern that cycles between periods of fasting and eating. It doesn't specify which foods to eat but rather when they are eaten.
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Any discussion of rejuvenation biotechnology will almost certainly include the subject of overpopulation and the objection that medical advances that directly address the various processes of aging will lead to an overpopulated world.
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The concern that rejuvenation biotechnologies might cause social disparity and further widen the gap between rich and poor is one of the most commonly raised ones, probably second only to concerns of overpopulation. Like many others, this concern may appear valid at first, but it does not survive careful analysis.
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Melatonin is mostly known for its crucial role in sleep-wake cycle regulation, but it is a versatile molecule that exhibits potent antioxidant, anti-inflammatory, anti-cancer, and immunomodulatory functions. It also has potential anti-aging properties.  
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