June 06, 2025
If you are in the Northern Hemisphere, then spring is well underway and the weather is warming up. This is the season of renewal and growth. With that in mind, let's take a look at what the Lifespan and LRI team has been up to. Top stories of Spring 2025 As always, we have been...
June 02, 2025
May was a substantial month in the rejuvenation biotechnology world, including nanomedical advancements, T cells to fight senescence, a transcription factor with multiple potential uses, and the Hallmarks of Aging lab discussing two more hallmarks. LEAF News Longevity Investor Network 2024 End of Year Update: Developing technologies to defeat age-related diseases by keeping people biologically...
May 29, 2025
A placebo-controlled clinical trial, with results published in Aging Cell, has determined that plasma replacement has beneficial effects when combined with immunoglobulin, according to multiple epigenetic clocks and -omics biomarkers. Looking for a signal Therapeutic plasma exchange (TPE), the practice of extracting and replacing a person's blood plasma with a saline solution containing albumin [1],...
May 23, 2025
A sub-study, which was part of the large-scale VITAL trial, determined that vitamin D supplementation slows telomere attrition in leukocytes almost to a halt. This could have real-life clinical implications [1]. The chromosome guardians Attrition of telomeres, repetitive sequences that cap chromosomes, is one of the original hallmarks of aging. Our cells' replication machinery does...
May 16, 2025
What is aging? Sadly, we don’t know. If we ask the experts in the field, they will give us different answers [1]. Consensus has not been reached on even the trivial definition of aging, let alone its primary mechanisms. But, can we cure aging without understanding it? I think not. Knowledge is essential to target...
May 15, 2025
The Hallmarks of Aging team has returned to Cell, publishing a detailed review discussing how future methods of dealing with aging might be highly personalized. Two more hallmarks? In the original and very heavily cited 2013 paper [1], Dr. López-Otín and colleagues outlined nine hallmarks of aging. In their 2023 update [2], three more were...
May 13, 2025
Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1]. How do we harness the immune system against senescence? Cellular senescence, which occurs when cells subjected to stress stop dividing and start emitting pro-inflammatory signals,...
May 07, 2025
In a recent study, lifelong, repeated microbiota transfer from young mice to old mice improves intestinal permeability, coordinative ability, and metabolic profiles while reducing pro-inflammatory responses [1]. Small in size, but mighty in impact Previous research has found that the composition and function of gut microbes (microbiota) changes as we age. These changes are linked...
May 01, 2025
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz von Foerster and colleagues, who extrapolated global population data to predict a so-called "Doomsday", a demographic singularity in which human numbers would become infinite by...
April 01, 2025
It's April Fool's Day, but until we prevent our bodies from gradually deteriorating, the joke will always be on us. Here's a no-fooling list of what's been done to fight aging last month. Interviews Joshua “Scotch” McClure: “Infectious Disease Drives Aging”: According to McClure, his company’s synthetic version of the ubiquitous but naturally unstable anti-microbial...
June 24, 2025
About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal External Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs Become a Host Lab News Latest News Our Ethics Code Interviews Editorials Op-Ed Investor Network About Join Reports Advocacy Video Initiatives Crowfunding Advocacy Topics Press Engagements Sponsored Projects...
June 24, 2025
About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal External Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs Become a Host Lab News Latest News Our Ethics Code Interviews Editorials Op-Ed Investor Network About Join Reports Advocacy Video Initiatives Crowfunding Advocacy Topics Press Engagements Sponsored Projects...
June 24, 2025
About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal External Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs Become a Host Lab News Latest News Our Ethics Code Interviews Editorials Op-Ed Investor Network About Join Reports Advocacy Video Initiatives Crowfunding Advocacy Topics Press Engagements Sponsored Projects...
June 17, 2025
About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal External Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs Become a Host Lab News Latest News Our Ethics Code Interviews Editorials Op-Ed Investor Network About Join Reports Advocacy Video Initiatives Crowfunding Advocacy Topics Press Engagements Sponsored Projects...
October 25, 2021
Science is Working on Therapies For Healthy Longevity People call it life extension, anti-aging, age-reversal, longevity research, geroscience, rejuvenation biotechnology, and even biomedical gerontology but what exactly is it? What life extension is While life extension is technically correct, it is somewhat more nuanced than simply just increasing lifespan. It describes the development of advanced...
September 26, 2024
Discover Topics About Longevity Our goal is to share evidence-based knowledge about aging and rejuvenation among the general public and cut through the misleading and confusing storm of information out there. With that in mind, we have created a range of topics covering supplements, exercise, diet, lifestyle and more for you to enjoy. These are...
July 26, 2018
MOTIVATIONAL Keith Comito at Ending Age-Related Diseases 2018 — One Second, One Life | LEAF. Dr. Aubrey de Grey at Ending Age-Related Diseases 2018 — Rejuvenation is Finally an Industry | LEAF. Life Extension: How to Reach a Societal Turning Point — Talk by Keith Comito at D.N.A. Conference. A Cure...
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August 09, 2024
Fountain Therapeutics is a biotech company founded by Thomas Rando, Joseph Rodgers, Tom Cheung. The San Francisco based company has developed an unbiased screening platform for new aging targets using AI, vision, & cellular model of aging hallmarks. Fountain’s mission is to develop a pipeline of therapeutics that treat the underlying cause of degenerative diseases by...
June 28, 2021
NOVOS is a nutraceutical company that develops science-based products to slow down aging with a global team of longevity scientists, MDs, and practitioners. Currently, the company offers two nutraceutical products, NOVOS Core and NOVOS Boost. Core contains 12 ingredients that the company believes can slow down aging. Boost contains one ingredient: nicotinamide mononucleotide (NMN). NOVOS'...
May 06, 2021
With a long history of funding successful tech startups in Germany, Kizoo Technology Ventures provides mentoring, seed funding, and early-stage financing to rejuvenation biotechnology companies. It is part of the Forever Healthy Group, the organization that sponsors the annual Undoing Aging conference, and its portfolio consists of companies that are developing interventions against multiple aspects...
April 17, 2021
Juvenescence is a biotech longevity company aiming to tackle aging and age-related diseases. This company aims to build a coalition of the best scientists, physicians and investors to develop therapies and products that could potentially help people enjoy longer and healthier lives. Juvenescence names the Buck Institute, the University of Pittsburgh, and Genomics England as...
April 27, 2020
Cambrian BioPharma is a distributed drug discovery company developing medicines to extend healthy lifespan. It bills itself as a distributed drug discovery company, and it aims to comprehensively treat the diseases of aging in the way that most infectious diseases were treated last century. Cambrian is organized in a way that its founders hope will...
January 24, 2020
GenSight Biologics is a clinical-stage biotechnology company discovering and developing novel therapies for neurodegenerative retinal diseases and diseases of the central nervous system. The London-based biotech company leverages two core technology platforms, the Mitochondrial Targeting Sequence (MTS) and optogenetics for retinitis pigmentosa, to help preserve or restore vision in patients suffering from severe degenerative retinal diseases....
December 05, 2019
Senolytic Therapeutics (STX) is developing proprietary strategies to destroy the senescent cells that generate the senescence-associated secretory phenotype (SASP) and harm tissues, thus treating one of the hallmarks of aging and associated age-related diseases. It has a treatment program focused on removing fibrotic tissue and treating specific kinds of cancer, is working on an immune...
December 05, 2019
Life Biosciences aims to bring top scientists together from the world's preeminent research and academic institutions into a discovery, development, and commercialization ecosystem dedicated to advancing treatments for age-related diseases. Founded in 2017 and headquartered in Boston, MA, they are pursuing clinical therapies across multiple molecular pathways that target each of the hallmarks of aging....
