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Tag: Metformin

Gene analysis
A paper published in GeroScience has described a gene responsible for a key biomarker of cellular senescence. A widely used biomarker Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical...
Sarcopenia
Researchers publishing in Aging Cell have documented a human clinical trial showing that metformin reduces atrophy caused by long periods of bed rest. A common problem and a well-known diabetes drug Long periods of disuse cause muscles to atrophy and accelerate the age-related muscle wasting known as sarcopenia [1]. Strength training is the accepted treatment...
Mouse eating
In a new study published in Aging Cell, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, reverse aging in a population of intestinal stem cells [1]. The aging intestine Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various...
Hands together mouse
Scientists have found that rapamycin and metformin work hand in hand in diabetes-prone mice, boosting each other's effectiveness and blocking side effects [1]. The combination hypothesis Rapamycin and metformin are probably the two most promising anti-aging drugs known. Both have been in use for various indications for decades and have decent safety profiles. However, there...
LSN Metformin VO2max
This episode of Lifespan News features Ryan O'Shea discussing a recent study showing that metformin blunts the impact of exercise on performance. Script Metformin is a commonly prescribed diabetes drug, but it is also popular among biohackers and life extensionists who take it for what they believe to be its longevity benefits. While this use...
Vascular brain
A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human disease In bilateral common carotid artery occlusion (BCCAO), the arteries of rats are sutured to reduce blood flow. This mimics arterial occlusion in human beings...