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Old Plasma Dilution Reduces Human Biological Age

Journal Club August 2022

Journal ClubJournal Club

The Journal Club returns to our Facebook page on Tuesday 30th August at 12:00 Eastern with your host, Dr. Oliver Medvedik.

This month, we investigate a paper, Old plasma dilution reduces human biological age: a clinical study, in which Irina Conboy and her team investigated the effects of therapeutic plasma exchange on aging in people. Previous experiments by the same team have focused on mice and demonstrated rejuvenation; this paper is the first step towards translating those results to humans. Could this be the first demonstration in people that aging can be reversed? Tune in to find out!


This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, human aging is driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age, defined in our work as a deregulation (noise) of 10 novel protein biomarkers. The results on biological age are strongly supported by the data, which demonstrates that rounds of therapeutic plasma exchange (TPE) promote a global shift to a younger systemic proteome, including youthfully restored pro-regenerative, anticancer, and apoptotic regulators and a youthful profile of myeloid/lymphoid markers in circulating cells, which have reduced cellular senescence and lower DNA damage. Mechanistically, the circulatory regulators of the JAK-STAT, MAPK, TGF-beta, NF-κB, and Toll-like receptor signaling pathways become more youthfully balanced through normalization of TLR4, which we define as a nodal point of this molecular rejuvenation. The significance of our findings is confirmed through big-data gene expression studies.

CategoryJournal Club, News
About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
  1. garvin timmann
    September 3, 2022

    Hi Steve, Its is Garvin again from Leagrave!

    This review of Old Plasma Dilution we are going to try.

    My father is above 65 years old. He did get assessed by ACE Alzheimer Barcelona, the Grifols group, after Ambar study. Approved for Therapeutic Plasma Exchange but other suggest the removal of the plasma by plasma donation is just the same with the isotonic saline solution replaced.

    The 5% Albumin is replaced with TPE, but at great financial cost. 18 session is EUR 30,600, where people donate plasma for free, albeit in smaller volume, but with more frequency.

    John from Birmingham in the video wants to try this. For people over 65 years, is there a way from the old plasma to just be removed?

  2. garvin timmann
    September 3, 2022

    Steve, I forgot to mention that in the UK in the NHS we can donate our plasma, but only up to the age of 65 years old.

    They clearly do not want old blood fractions.

    I’m heading to Twickenham, Donor Centre, Floor 8, Regal House, 70 London Road, TWICKENHAM, TW1 3QS, which is our nearest.

    For John there is Birmingham Plasma Donor Centre
    65 New Street, Birmingham, B2 4DU

    There is another plasma donation centre Reading Plasma Donor Centre, Kennett Place, 121 King’s Road, Reading, RG1 3ES.

    In the UK there is only these three locations for plasma donation.

    • Steve Hill
      September 7, 2022

      I am in the UK so this is useful information, thanks!

      • pr
        September 8, 2022

        Steve, I am going to give plasma tomorrow (9th September) at Twickenham. I figure I am about the same age as you, I’m 43 years old. So my question is regarding Irena Conboy’s Blood Plasma fraction:

        When is the blood old and needing dilution/ removal?

      • garvin timmann
        September 10, 2022

        Irina Conboy has stated: ” It doesn’t seem that albumin is the main factor in the system, there was no dramatic change in effect when albumin was not included.”

        So it is in fact old plasma removal that is the benefit, not 5% albumin replacement.

        I donated based on my age (43), weight (17stone), Height (6ft 6in), 700ml of plasma only. I felt a bit tingly, perhaps the blood pressure altered slightly, drove back to Leagrave from Twickenham, and wad told this can be done every 3 weeks. It took one hour.

        For people over 65 years the NHS do not want plasma, so they are aware of the negative factors in old to elderly plasma.

        For people in the UK this is what needs to be rectified for plasma removal only in old age, not plasma donation of old blood.

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