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Journal Club February – Mitochondria Can Trigger Cellular Senescence

An HDAC inhibitor may suppress that signaling to delay senescence.

Journal ClubJournal Club
 

Join Dr. Oliver Medvedik at 12:00 Eastern, February 25th for the Journal Club livestreamed on our Facebook page.

Researchers have discovered that mitochondria trigger cellular senescence through communication with the cell’s nucleus and identified that a HDAC inhibitor, an FDA-approved drug, helped suppress the damaging effects of the condition in cells and mice. The discovery could lead to treatments that promote healthy aging or prevent age-associated diseases.

Literature

Vizioli, M. G., Liu, T., Miller, K. N., Robertson, N. A., Gilroy, K., Lagnado, A. B., … & Adams, P. D. (2020). Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence. Genes & development, 34(5-6), 428-445.

About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
  1. mpease
    February 27, 2021

    Sounds interesting. I missed the life JC, will it be uploaded to the YT channel? Thanks!

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