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Tag: Cellular Senescence

January 22, 2021
A new study by a team of researchers, including Dr. Kirkland of Mayo Clinic, shows the effect of whole-body senolytic treatment on the health and function of the brain. This follows up on previous Mayo Clinic research led by Dr. James Kirkland. That experiment treated mice with a combination of the cancer drug dasatinib and...
January 19, 2021
A group of scientists has created a neural network that identifies senescent cells by their morphology and can be used for senolytic drug screening [1]. Image recognition is a showcase triumph of artificial intelligence. While this problem was considered extremely hard to crack in previous decades, algorithms have now exceeded human abilities in multiple cases....
January 13, 2021
Researchers publishing in Frontiers of Aging Neuroscience Journal have discovered a new way in which senescent cells contribute to aging and chronic disease. Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals,...
January 12, 2021
A new review paper delivers evidence that exercise, a powerful anti-aging tool, may be a natural senolytic [1]. Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known as the senescence-associated...
January 08, 2021
A few years ago, a team at Mayo Clinic led by Dr. James Kirkland treated mice with the cancer drug dasatinib and the popular dietary supplement quercetin, with results suggesting that the combination was able to destroy senescent cells. This combination was part of the first generation of drugs known as senolytics, compounds that encourage...
January 04, 2021
The results of a recent study suggest that fisetin appears to reduce the development of bleomycin-induced pulmonary fibrosis [1]. Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its basic chemical characteristics were...