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Tag: Cellular senescence

October 16, 2020
Insilico Medicine has announced a historic deal with the Taisho Pharmaceutical Company, which is based in Japan, in a partnership to identify and develop new senolytic drugs. The companies have agreed to collaborate on AI-powered drug discovery focused on identifying molecules to remove problematic senescent cells. Cellular SenescenceAs your body ages, more of your cells...
October 15, 2020
A new study published in Nature shows a strong link between the protein G3BP1 and the SASP, a harmful byproduct of senescent cells.
October 13, 2020
Unity Biotechnology has recently announced the launch of its Phase 1 study of UBX1325 for patients with diabetic macular edema. The drug is designed to remove problematic senescent cells from the body which accumulate as we get older and are a reason we age. Cellular SenescenceAs your body ages, more of your cells become senescent....
October 08, 2020
Genes in the sirtuin family are conserved across a wide range of species and are involved in cellular metabolism, immune response, and aging. SIRT1 is known to decline during aging, but the mechanisms involved in this process were not known. Now, an international team has clarified how SIRT1 is regulated during cellular senescence [1]. Cellular...
September 28, 2020
Researchers have published a new animal study showing that the plant flavonoid naringenin may be useful in targeting problematic senescent cells in the brain. Ribes meyeri (also known as Ribes meyeri maxim) is a native plant to central Asia, Mongolia and Northeast Afghanistan and is part of the Saxifragaceae family and the Ribes genus; this...
September 17, 2020
Researchers have discovered that removing senescent-like neurons alleviates peripheral neuropathy caused by cisplatin, a powerful chemotherapy drug, in mice. Cisplatin As the researchers of this study explain, cisplatin is a chemotherapy drug that works by causing platination in nuclear DNA, which leads to cellular failure, senescence, and death. While this is effective against cancer, this...