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Tag: Cellular Senescence

Baton passing
Scientists have shown that extracellular vesicles derived from senescent stem cells can improve the proliferation, viability, and migration capacity of healthy stem cells [1]. Cell-to-cell packages Extracellular vesicles (EVs, not to be confused with electric vehicles) are tiny membrane-bound bubbles that are emitted by cells and carry various molecular cargo such as proteins and miRNA....
Elderly smiling
A team of researchers has recently published a study on the effects of senescence on periodontal tissues in Aging. Connecting bones and teeth We have previously outlined a study showing a relationship between gum disease and biomarkers of inflammation. Noting that aging itself is a risk factor for periodontitis [1], this study approaches this topic...
Extracellular vesicles
A review paper published in Cells has described multiple ways in which the secretion of extracellular vesicles (EVs) changes with aging, leading the authors to propose it as its own hallmark. Extracellular vesicles and their uses This review begins with an outline and explanation of extracellular vesicles and their classifications. Cells use extracellular vesicles to...
Brain tumor
Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly, aggressive, and hard to treat Glioblastoma is one of the most dangerous forms of cancer. Even surgery, radiotherapy, and chemotherapy do little against this invasive...
Old DNA
Scientists have found that the remnants of the ancient retrovirus family HERVK, which reside in our genome, are transcribed more frequently in aged cells. This is caused by cellular senescence and accelerates it, including in the neighboring cells, when those are infected by retroviral particles [1]. Hitchhiker's guide to the genome Retroviruses, such as HIV,...
Research published in Nature Aging has shown that a photosensitive senolytic drug can be used to selectively remove senescent cells, slowing functional organ aging in mice. A problem of delivery What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and cling onto...