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Tag: Cellular Senescence

Research mouse
April 14, 2021
A new study in Molecular Cell has shown that the benefits of hypoxia may be derived from a suppression of the inflammatory SASP. Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals,...
April 08, 2021
A lipid metabolite could serve as a novel biomarker to test the performance of senolytics, according to a new study [1]. Such a biomarker can be detected from blood or urine, allowing for non-invasive testing, and experiments have shown that it plays a functional role in cellular senescence. Slowing down to stay safe Cellular senescence...
March 31, 2021
Scientists have alleviated symptoms of the rare premature aging disease ataxia-telangiectasia using NAD+ supplementation in a mouse model [1]. This success deepens our understanding of the role NAD+ plays in aging. The ubiquitous facilitator The coenzyme nicotinamide adenine dinucleotide (NAD+) is one of the foundations of life as we know it, and it may have...
Exosomes
March 24, 2021
A new study in Aging Cell has shown extracellular vesicles from stem cells to extend healthspan and reduce cellular senescence in vitro and in mice. Stem cell exhaustion is a well-studied hallmark of aging that occurs in multiple model organisms and multiple tissue types in humans. This has led to the hypothesis that bolstering these...
February 21, 2021
Join Dr. Oliver Medvedik at 12:00 Eastern, February 25th for the Journal Club livestreamed on our Facebook page. Researchers have discovered that mitochondria trigger cellular senescence through communication with the cell's nucleus and identified that a HDAC inhibitor, an FDA-approved drug, helped suppress the damaging effects of the condition in cells and mice. The discovery...
Complicated machinery
February 12, 2021
Aging is a multifactorial and complex process; indeed, it is probably the most complex disorder known. It is made up of a combination of dozens of malfunctions locked together in an accelerating spiral of decline. Despite this undeniable complexity, which is captured to some extent by grouping the many age-related dysfunctions into nine categories often...