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Tag: Cellular Senescence

Spinal Disc Degeneration
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were not built to last for as long as humans...
Intercellular Communication
Today, we want to highlight a recent review that charts the pro-inflammatory signals produced by senescent cells [1]. What is the senescence-associated secretory phenotype? As we grow older, an increasing number of aged cells in our body enter a state called senescence. At this point, the cells no longer divide and, under normal conditions, should...
Removing senescent cells with senolytics may reverse some aspects of aging.
In this article we will take a look at senolytics and how they have the potential to reverse some aspects of the aging process. Senescent cells and aging As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of which they...
Heart Inflammation
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive oxygen species (ROS) [2]. The researchers hypothesized that ROS,...
Hair Loss
Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair follicles Hair follicles reside in the epidermal and dermal skin layers. At their base is the dermal papilla, where hair growth is controlled by dermal...
Capers are high in quercetin which may help slow down aging.
Found in many fruits and vegetables, quercetin may have some potential in the context of aging. We take a look at this natural compound and popular dietary supplement. What is quercetin? Quercetin is a natural flavonoid, which makes it part of a large family of water-soluble plant compounds. Flavonoids are not created by the body...