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Glucosamine Supplementation Correlates With Reduced All-Cause Mortality

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It is one of the most commonly used supplements frequently taken to address joint pain, but there might be more to this dietary supplement than first meets the eye.

Glucosamine was originally discovered during the 1960s in Italy by pharmacologist Professor Luigi Rovati. Glucosamine is one of the most commonly used dietary supplements and is typically taken to help with the joint pain and inflammation associated with aging.

Glucosamine is a polysaccharide that is found naturally in cartilaginous joint tissues, bones, skin, ligaments, and nails, and it is involved in protein and lipid synthesis. In the context of joints, synovial fluid contains glucosamine and occupies the space between joints, helping to reduce the friction of joint surfaces.

Despite it being frequently taken for arthritis, the evidence for its effectiveness is limited, although, there is data for it being anti-inflammatory, as suggested by the results of a randomized clinical trial in 2015 [1].

However, glucosamine supplementation seems to correlate with lower all-cause mortality and other mortality risks, such as cardiovascular disease (CVD), cancer, respiratory and digestive diseases. A recent analysis published in the journal BMJ showed that glucosamine supplementation conveys around a 15% reduction of all-cause mortality [2]. This is a considerable amount when compared to other lifestyle interventions as well as other supplements. The data gathered is from a large number of people, and the trend of reduced mortality is unmistakable.



This population-based prospective cohort study included 495 077 women and men (mean (SD) age, 56.6 (8.1) years) from the UK Biobank study. Participants were recruited from 2006 to 2010 and were followed up through 2018. We evaluated all-cause mortality and mortality due to cardiovascular disease (CVD), cancer, respiratory and digestive disease. HRs and 95% CIs for all-cause and cause-specific mortality were calculated using Cox proportional hazards models with adjustment for potential confounding variables.

Regular glucosamine supplementation was associated with lower mortality due to all causes, cancer, CVD, respiratory and digestive diseases.

Conclusion

The exact reasons for this correlation with the reduction of various mortality risks is as yet unknown, but given the large patient group in this and in other analyses along with the popularity of this supplement, it is impossible to deny that there is a definite trend here.

We are not suggesting that you take this supplement, but given that it is cheap and freely available with an excellent safety profile, it may be worth your consideration and further research to evaluate if you wish to take it or not.

Literature



[1] Navarro, S. L., White, E., Kantor, E. D., Zhang, Y., Rho, J., Song, X., … & Lampe, J. W. (2015). Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PloS one, 10(2), e0117534.

[2] Li, Z. H., Gao, X., Chung, V. C., Zhong, W. F., Fu, Q., Lv, Y. B., … & Li, F. R. (2020). Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Annals of the Rheumatic Diseases, 79(6), 829-836.

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About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 500 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
  1. boo_ky_monster
    July 31, 2020

    I personally thank the inventor of this wonder pill, I was up against a wall and my shape was drawn, I stood crooked, a chiropractor wanted to adjust me but instead I found glucosamine in 2007, at that time I was in pain, couldn’t stand for long periods of time I took 11 pills a day for a month and my skeletal frame became straight with little pain to speak of today. It is now 2020 and I take 5 pills a day, the reason being is; I have DDD, Osteoarthritis and Arthritis, I will never get better but life is good when you don’t have pain daily.
    Thank you again for the making of glucosamine and if there’s anything else I can take please let me know. :)
    Happy user.

  2. janetroberts914
    August 1, 2020

    Can it help with a tendon tear? what is some of the health benefits of glucosamine?

  3. dcalvente
    August 1, 2020

    I have been taking it together with chondroitin and MSM for four months for three capsules a day.
    I had severe pain in the joints of one hand and several of them were deformed.
    Now they don’t hurt at all, mobility is perfect and bone deformations are gradually disappearing.
    I am absolutely happy with this result, since my osteoarthritis is hereditary and seems to have stopped.

    • soniahustad
      August 2, 2020

      What do you mean you are experincing bone deformation?

  4. Deane Williams
    August 3, 2020

    Steve, the most likely reason that glucosamine is good for the body (and not just your joints) is that it is very good for your mitochondria. Read this:
    (from Dr. Michael Ristow) Back in 2007 when we showed that increased ROS extends lifespan in C. elegans, we used a compound that completely blocks glucose metabolism, deoxyglucose. Since the cell can’t metabolize glucose anymore, it enters an energy deficit similar to starvation, and responds by switching on its mitochondria. It turned out to be toxic in mice. Then a student in my lab said, “Why don’t we use glucosamine?” Glucosamine only slightly inhibits glucose metabolism (glycolysis), and it’s known to be completely harmless to humans. It’s like the cell being on a diet: it still activates its mitochondria, still produces a bit more ROS, but not to the excessive level that it would with deoxyglucose. We took two year old mice, which is equivalent to something like 55 or 60 in humans, and gave them glucosamine, which caused both males and females to live longer. The effect was stronger in females, but it was independently detectable in both sexes.

  5. theonolte
    September 17, 2020

    For those who want to try, here is some info i found on the internet:

    Glucosamine is available as sulfate or hydrochloride (HCL). The sulfate is 74% pure and often comes as a pill, the HCL is 99% pure and a white powder. There is more data about the sulfate as it has been used in most studies, but the HCL is considered as effective.

    Glucosamine is often sold in combination with chondroitin, but the study concludes that chondroitin does not contribute to the benefits.

    Regrettably there is no mention of the dosage, but googling suggests that 1g/day is considered ok.

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  1. July 31, 2020

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