November 25, 2024
In Aging, researchers have reported that deriving extracellular vesicles from mesenchymal stromal cells (MSCs) in fat tissue has beneficial effects in models of osteoarthritis. Which source to use? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...
November 07, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells' function Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
August 12, 2024
In Aging Cell, researchers have published details on the pathway by which a compound commonly found in ketone bodies ameliorates osteoarthritis in a rat model. Chondrocytes are crucial in arthritis The cartilage holding joints together is built and maintained by chondrocytes, which synthesize such necessary proteins as collagen and aggrecan [1]. Unfortunately, the cellular senescence...
July 22, 2024
In iScience, researchers have explained how physical mechanics can alter mitochondrial function in a way that leads to osteoarthritis. When simple physics affects biology Previous work has pinpointed abnormal mechanical loading, which occurs when joints are placed under excessive stresses in ways that they were not meant to handle, as a key driver of osteoarthritis...
February 20, 2024
Rejuvenate Bio has announced a partnership with a leading animal health company to develop a gene therapy for canine osteoarthritis. The identity of the partnering global company is as yet unknown. This San Diego-based biotech was co-founded in 2017 by Professor George Church of Harvard Medical School. It is focused on dog longevity research and...
January 08, 2024
Researchers have described how specialized nanoparticles, which deliver rapamycin and the antioxidant astaxanthin, restore macrophage balance and reduce inflammation in a mouse model of osteoarthritis. A matter of polarization Inflammation is a critical part of arthritis. Previous studies have found that inflammation of the membranes in joints (synovitis) strongly contributes to osteoarthritis [1]; in fact,...