Tag: Osteoarthritis

Resarchers publishing in Aging have found that extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (MSCs) reduce inflammatory markers in chondrocytes, which are responsible for building and maintaining human cartilage. An established approach This is far from the first attempt at treating osteoarthritis using stem cells. We have previously reported on a...

In a new study published in Scientific Reports, researchers have uncovered the molecular mechanism underlying the link between obesity and joint degeneration [1]. Obesity and osteoarthritis Obesity accelerates aging and is associated with several age-associated diseases, including osteoarthritis, an inflammatory condition that leads to joint degeneration. Obesity is often accompanied by low-grade chronic inflammation, which...

Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1]. Systemic administration Osteoarthritis, a degenerative joint disease, is one of the most common causes of disability in old age. By limiting the ability to maintain...

Publishing in Aging, a team of Spanish researchers has found that changing the mitochondria of standard Black 6 mice leads to marked improvements in joint health. Conplastic mice The Black 6 mouse is well-known in research as a standard in the industry. However, it is not nearly a perfect mouse in terms of ability or...

In a paper published in Nature Aging, a group of scientists outlines a previously unknown pathway that leads to osteoarthritis and describes a promising treatment [1]. Less than a killer, more than a nuisance There are plenty of deadly age-related diseases, and then there are others that shorten our healthspan rather than lifespan, making the...

A study published in Aging has found that osteopontin's effects on bone remodeling may be at least partially responsible for osteoarthritis. BoneBone tissue serves as the primary structural component of our bodies. It protects our delicate inner organs, plays a key role in whole body calcium, phosphorus, and acid-base homeostasis, and allows movement to occur...