February 19, 2020
Researchers from Berkeley have established that SIRT2 prevents overactivation of the NLRP3 inflammasome through deacetylation. Targeting this pathway can possibly reduce or even reverse age-related chronic inflammation and insulin resistance. What are sirtuins? Sirtuins are a family of proteins that have long been a target of longevity research [1]. Sirtuins probably descend from some of...
June 26, 2019
Today, we want to highlight a new publication that looks at cytomegalovirus (CMV) and its potential role in the development of metabolic syndrome. What is cytomegalovirus? CMV is part of the β-subfamily of herpes viruses, a family of viruses that are believed to have been co-evolving with their hosts for around 180 million years [1]....
April 18, 2019
The results of a clinical trial using bone marrow-derived mesenchymal stromal cells (MSCs) to treat late-stage knee osteoarthritis were published recently, and they came back positive. The trial included both phase 1 and 2 and was designed to determine the safety and efficacy of MSC stem cell therapy. A battery of tests During the trial,...
September 26, 2018
A study from the UNC School of Medicine showed that the protein NLRP12, known for its anti-inflammatory effects, also protects mice on a high-fat diet against obesity and insulin resistance; it might have a similar effect in humans [1]. Study abstract In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to...
September 19, 2018
Today, we want to draw your attention to a new study that looks at the role of chronic age-related inflammation and the decline of nerve regeneration. Inflammaging drives age-related loss of tissue regeneration Inflammation can be beneficial and serves an important purpose: it spurs regeneration and immune responses while combating pathogens and other invaders. This...
September 17, 2018
According to a new study performed by University of Illinois researchers and published in Frontiers in Immunology, a diet rich in fiber reduces inflammation in aged mice, both in the guts and the brain. This beneficial reduction is due to high levels of butyrate, which result from the fermentation of fiber during digestion [1]. Study...
