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Tag: Inflammation

January 08, 2021
A few years ago, a team at Mayo Clinic led by Dr. James Kirkland treated mice with the cancer drug dasatinib and the popular dietary supplement quercetin, with results suggesting that the combination was able to destroy senescent cells. This combination was part of the first generation of drugs known as senolytics, compounds that encourage...
Targeting tumors
September 29, 2020
A group of researchers have devised an effective anti-cancer therapy by loading cytokine-coding RNA fragments into lipid nanoparticles and injecting them directly into the tumor [1]. Anti-cancer immunotherapy is a powerful novel strategy that has given hope to millions of cancer patients. The immune system has a few aces up its sleeve when fighting cancer,...
August 24, 2020
A new review takes a look at the association between the decline of the immune system and the development and course of age-related diseases. Our immune system is the ultimate defense against invading pathogens and unwanted waste, and its efficient operation is critical to the healthy function of every tissue in the body. We have...
Glucosamine in ball-and-stick form
July 31, 2020
It is one of the most commonly used supplements frequently taken to address joint pain, but there might be more to this dietary supplement than first meets the eye. Glucosamine was originally discovered during the 1960s in Italy by pharmacologist Professor Luigi Rovati. Glucosamine is one of the most commonly used dietary supplements and is...
Macrophage engulfing bacteria
April 15, 2020
Researchers have found that a protein called TIM-4 is essential to macrophages' ability to clean up cellular debris and that p38 MAPK, a protein that increases due to aging, inhibits TIM-4. Inflammaging and immunosenescence Aging is the primary risk factor for a myriad of chronic age-related diseases, including heart disease, Parkinson's, Alzheimer's, and cancer. As...
Bacon brain
March 10, 2020
Researchers from the Medical College of Georgia have demonstrated in a new study that visceral fat is harmful to the brain because it allows the inflammatory cytokine interleukin-1 beta to heavily infiltrate the brain [1]. It is well established that excessive amounts of visceral fat tissue is detrimental to health in the long term. Excessive...