August 24, 2020
A new review takes a look at the association between the decline of the immune system and the development and course of age-related diseases. Our immune system is the ultimate defense against invading pathogens and unwanted waste, and its efficient operation is critical to the healthy function of every tissue in the body. We have...
July 31, 2020
It is one of the most commonly used supplements frequently taken to address joint pain, but there might be more to this dietary supplement than first meets the eye. Glucosamine was originally discovered during the 1960s in Italy by pharmacologist Professor Luigi Rovati. Glucosamine is one of the most commonly used dietary supplements and is...
April 15, 2020
Researchers have found that a protein called TIM-4 is essential to macrophages' ability to clean up cellular debris and that p38 MAPK, a protein that increases due to aging, inhibits TIM-4. Inflammaging and immunosenescence Aging is the primary risk factor for a myriad of chronic age-related diseases, including heart disease, Parkinson's, Alzheimer's, and cancer. As...
March 10, 2020
Researchers from the Medical College of Georgia have demonstrated in a new study that visceral fat is harmful to the brain because it allows the inflammatory cytokine interleukin-1 beta to heavily infiltrate the brain [1]. It is well established that excessive amounts of visceral fat tissue is detrimental to health in the long term. Excessive...
March 06, 2020
New research suggests that the very immune cells that protect our brain can eventually start attacking it due to chronic systemic inflammation, something that is typically present in older people. The blood-brain barrier The blood-brain barrier (BBB) surrounds most of the blood vessels in the brain and forms a protective barrier between the bloodstream and...
February 19, 2020
Researchers from Berkeley have established that SIRT2 prevents overactivation of the NLRP3 inflammasome through deacetylation. Targeting this pathway can possibly reduce or even reverse age-related chronic inflammation and insulin resistance. What are sirtuins? Sirtuins are a family of proteins that have long been a target of longevity research [1]. Sirtuins probably descend from some of...
