Tag: Inflammation

A new study has identified a molecule found in Saposhnikovia root as a potent mediator of tendon regeneration in rats. The results were also replicated in human cells [1]. Aging does not spare tendons Like with many tissues, the health of tendons, which are central to mobility and agility, hinges on the function of local...

Researchers publishing in Aging have explained a relationship between inflammation, metabolic syndrome, and prostate enlargement. Not so benign Benign prostatic hyperplasia (BPH) is only called 'benign' to differentiate it from another well-known cause of prostate enlargement: prostate cancer. BPH is known to lead to bladder obstruction and lower urinary tract issues. It also coincides with...

An article in GeroScience describes a previously unexplored relationship between FABP7, an inflammatory molecule that binds to fatty acids, and Alzheimer's disease. Not just a transporter Originally, as the authors explain, fatty acid binding proteins (FABPs) were considered to be simple biological chaperones that did not perform biological functions. Further research found that they play...

In a paper published in Geroscience, researchers have developed a metric of systemic inflammation and used it to estimate mortality, finding that it performs better than epigenetic clocks. Evaluating a danger What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read More...

Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating a cause-and-effect relationship between initial damage and long-term effects. Perturbed mitochondria release their mitochondrial DNA (mtDNA) into the internal liquid (cytosol) of microglia, the helper...

Researchers publishing in Journal of Toxicology and Environmental Health, Part B have found that the common sweetener sucralose may contribute to genetic and intestinal damage [1]. Not the only study of this kind This paper begins by stating the fundamental claims that were made prior to the approval of sucralose by the FDA. Those claims...