Help us: Donate
Follow us on:
×

Menu

Back

Month: January 2019

For the January Journal Club, we discussed the recent human senolytics trial conducted at the Mayo Clinic. Abstract Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin...
A new aging clock developed by Professor Steve Horvath and his research team takes measuring your biological age a step further and can accurately predict your future lifespan. The epigenetic clock As we age, our DNA experiences chemical changes called DNA methylation (DNAm); these changes are used as a way to measure age and are...
(The intercom buzzes in Death's office.) — Mr. Death, sir, Mr. Flores is here. — (Slightly surprised, Death takes a look at his wrist hourglass.) Already? I wasn't expecting him so early. Well, let him in anyway, Miss Coffins. (Miss Coffins shows Mr. Flores in. He cautiously looks around, confused.) — Ah, Mr. Flores! Welcome....
UNITY Biotechnologies has recently announced an expansion of its first-stage human trial of UBX0101, a drug that has been shown to have senolytic properties in mice [1] and that the company hopes will be useful in treating painful osteoarthritis of the knee. An expanded clinical trial UNITY Biotechnologies, a $495 million biotech company in the...
While medical schools have had the idea that aging should be brought under medical control for over a century, the explicit desire to greatly extend one's life remained rare - until very recently. A new study by YouGov, a market intelligence company that researches multiple topics, found that, today, one in five Americans agrees with...
The complex relationship between the microbiome and the rest of the body has only recently started to become truly appreciated. The bacteria of the gut are increasingly looking like a potential player in aging, and some bacteria in the mouth associated with chronic periodontitis may be linked to Alzheimer's disease [1]. University of Louisville researcher...