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Tag: SASP

Stuck together
In a preprint paper, scientists have reported that senescent cells transiently adhere to neighboring cells, and, upon departure, leave in place large membrane-enclosed fragments of themselves [1]. Mysterious fragments Cellular senescence is central to aging, but there are still a lot of unknowns around this complex and heterogeneous phenomenon. For instance, we know that senescent...
Using a novel senolytic drug, scientists have successfully eliminated senescent cells in human skin transplanted into mice. The treatment led to prolonged skin rejuvenation [1]. Senescence and senolytics Senescent cells, also known as “zombie cells”, are cells that have stopped proliferating after being subjected to any of several types of stress (replicative, chemical, radiational, etc.)...
Blood cancer
New research published in Cancer Discovery has outlined a potential new method of using senescent cells to encourage the immune system to attack cancer [1]. Senescent cancer cells and immune clearance Cellular senescence is a stress response [2], and cancer cells within tumors undergo significant stress: they lose access to oxygen and nutrients, they divide...
Mouse test
Researchers publishing in Nature Communications have detailed how the removal of p16-producing senescent cells leads to improvements in the brains of female mice [1]. Disease-associated microglia and senescence This paper begins with a discussion of disease-associated microglia (DAM) and white matter-associated microglia (WAM). In the aging brain, these exhausted microglia have downregulated genes relating to...
Skin fibroblast
Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice. The spread of the SASP Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues...
Scientists have improved the potential effectiveness of a stem cell therapy for osteoarthritis by targeting senescent cells [1]. Stem cell exhaustion and osteoarthritis Osteoarthritis is an age-related disease that affects joints by degrading cartilage. While not fatal in itself, osteoarthritis negatively affects mobility and quality of life, and it can decrease lifespan and healthspan. Several...