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Tag: SASP

Young to old
Researchers have described an intermediary state between senescent and young cells, the inflammatory problems caused by these cells, and how young cells secrete a protein that may alleviate these problems. What happens before senescence? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support...
Older man exercising
A new review summarizes our knowledge about lifestyle interventions, such as exercise, healthy diet, and good sleep, that can possibly reduce cellular senescence [1]. What do we do with a senescent cell? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues...
Cells and DNA
Scientists have found that leakage of mitochondrial DNA in senescent cells is a major cause of their pro-inflammatory activity, and it can be targeted without clearing those cells out [1]. A new aspect of senescence Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or...
Lower back pain
In a recent paper, researchers from McGill University in Canada have investigated how a combination of two senolytics, RG-7112 and o-Vanillin, influences the intervertebral disc cells of back pain patients [1]. Back pain is a widespread issue An overwhelming majority of people, a full 80%, have suffered from back pain at some point in their...
Mouse on hand
In a research paper published in GeroScience, researchers investigated the impact of senolytics on young mice and found some surprising results [1]. Senescent cell removal and other properties Senolytics, when given to older mice, clear senescent cells. Senolytics such as fisetin and quercetin also have anti-inflammatory properties and can be used as chemotherapeutics and senotherapeutics...
Ginkgo Biloba
Researchers publishing in Aging Cell have documented some potential effects of rutin against senescence and cancer. Rutin is a natural compound found in several plants. Another compound to fight senescence In this study, the researchers place rutin among the many other natural compounds that have demonstrated effectiveness in the lab against cellular senescence, including fisetin...