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Tag: SASP

Death sentence
Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase inhibitor p21, which is encoded by the Cdkn1a gene, is associated with its own secretome: the p21-associated secretory phenotype (PASP). Similar but not identical to...
Lorna Harries Interview
Lorna Harries is a Professor of Molecular Genetics at the University of Exeter Medical School. She is also the CSO and R&D lead at SENISCA Ltd. Like many other companies, and as evidenced by the name, SENISCA targets senescent cells, albeit using an unusual mRNA-based approach. After Lorna gave a fascinating talk at our Ending...
Research fundamentals
Two of the most prominent experts in the field have published a review of cellular senescence in the context of metabolism, and we bring you the highlights [1]. We rarely cover review papers, but when Cristopher D. Wiley and Judith Campisi, two of the most prominent experts on senescent cells, publish a review on senescence...
Intercellular Communication
Today, we want to highlight a recent review that charts the pro-inflammatory signals produced by senescent cells [1]. What is the senescence-associated secretory phenotype? As we grow older, an increasing number of aged cells in our body enter a state called senescence. At this point, the cells no longer divide and, under normal conditions, should...
Capers are high in quercetin which may help slow down aging.
Found in many fruits and vegetables, quercetin may have some potential in the context of aging. We take a look at this natural compound and popular dietary supplement. What is quercetin? Quercetin is a natural flavonoid, which makes it part of a large family of water-soluble plant compounds. Flavonoids are not created by the body...
Storm
Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause of the cytokine storm, an immune overreaction that is more common in the elderly and is known to cause severe dysfunction and even death when...