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Tag: SASP

Bad news
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, can lead to cellular senescence. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead,...
Bosu exercise
A new study published in Aging Cell shows that a 12-week program of structured exercise lowers the activity of the inflammatory SASP in people in their mid-60s. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
RNA strand
New research has identified a set of long noncoding RNAs involved in inflammaging and the senescence-associated secretory phenotype (SASP) [1]. These RNAs are conserved across a range of species, including humans, and may prove a valuable avenue for controlling senescence. Age-related RNAs RNA can broadly be divided into protein-coding RNAs and noncoding RNAs, which have...
Research mouse
A new study in Molecular Cell has shown that the benefits of hypoxia may be derived from a suppression of the inflammatory SASP. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...
the retina
A review published in the Journal of Neuroinflammation explores the potential application of senotherapies, particularly in the context of treating age-related macular degeneration [1]. Introducing cellular senescence One of the most advanced approaches to treating aging and age-related diseases is that of addressing the presence of harmful senescent cells, which begin to accumulate with advancing...
Dr. Judith Campisi
At Ending Age-Related Diseases 2020, Prof. Judith Campisi of the Buck Institute for Research on Aging discussed the effects and usage of senolytics, drugs that remove senescent cells from the body. She went into the details of the stress and damage signals that cause cells to become senescent and the markers of senescent cells, noting...