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Tag: SASP

Liver in hand
Research published in Aging has shed new light on the relationship between certain liver diseases and cellular senescence. Clogged bile ducts and senescence Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...
Adrenal glands
A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and sex differences. A closer look at age-related cancer Over 90% of cancer diagnoses are made in people over a half century old [1]. This is not just because of genomic instability leading to cancerous mutations;...
Bone protection
Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects Zoledronate has already been approved by the FDA for clinical use, as it has been prescribed to prevent bone fractures in vulnerable people for more...
Brain synapses
Researchers have published a study in Aging Cell on how inhibiting the death of axons in the brain protects the brains of old mice from inflammation. Necroptosis in the brain It is well-known that aged organisms have problems with cognitive function, and this is strongly linked to losses in the number and availability of synapses...
Elderly smiling
A team of researchers has recently published a study on the effects of senescence on periodontal tissues in Aging. Connecting bones and teeth We have previously outlined a study showing a relationship between gum disease and biomarkers of inflammation. Noting that aging itself is a risk factor for periodontitis [1], this study approaches this topic...
Brain tumor
Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly, aggressive, and hard to treat Glioblastoma is one of the most dangerous forms of cancer. Even surgery, radiotherapy, and chemotherapy do little against this invasive...