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Tag: Parkinson's

July 26, 2019
Researchers from the Beijing Institute of Brain Disorders have discovered a new method of using exosomes to deliver aptamers that prevent the accumulation of α-synuclein aggregates, which are the cause of Parkinson's disease [1]. α-Synuclein Aggregates Like Alzheimer's, Parkinson's disease is characterized by protein aggregation caused by a loss of proteostasis, one of the hallmarks...
June 12, 2019
Today, we want to point out a new publication that recently appeared in the Science Translational Medicine journal, as its authors have discovered a new mechanism by which the brain protects itself from the harmful α-synuclein protein aggregates associated with Parkinson's and that may open the door to new therapies against these conditions. To understand...
April 09, 2019
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause of cognitive decline Microglia are immune cells that reside...
November 23, 2018
In a world first, a patient with Parkinson's disease has undergone transplant therapy, which uses reprogrammed stem cells to replace neurons destroyed by the disease. Stem cell therapy is part of the toolkit The stem cell field is an area of science that is relatively well funded and, out of all the branches of medical...
November 20, 2018
Researchers at Georgetown University Medical Center discovered that the protease USP13 (ubiquitin-specific peptidase 13) plays a role in the accumulation of toxic alpha-synuclein aggregates that characterize Parkinson's disease [1]. Abstract Ubiquitin specific proteases (USPs) are de-ubiquitinases that control the protein ubiquitination cycle. The role of de-ubiquitinases is poorly understood in neurodegenerative diseases. We found that...
October 08, 2018
Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer's, Parkinson's, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share. Misfolded proteins cause multiple age-related diseases Proteins are...