Tag: Parkinson's

In the Journal of Inflammation, researchers from Johns Hopkins University have published a detailed review of the relationship between brain inflammation and the principal diseases of dementia. A focus on genetics and environment One out of twenty Americans over 85 have Parkinson's disease [1], and seven out of twenty have Alzheimer's [2]. While genes are...

A team of researchers publishing in Nature Communications has described nanobodies that can destroy the α-synuclein aggregates that characterize Lewy bodies, which are associated with dementia and Parkinson's disease [1]. What are nanobodies? Traditional antibody therapies, while promising in some studies, are too large to enter cells in order to affect the aggregates there [2]....

Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three different classes of neurodegenerative protein disorders: TDP-43 proteinopathies, such...

A study published in Cell Reports has found α-synuclein, the fundamental protein of Parkinson's disease, to be critical in immune function. The gut-brain axis as a channel for disease Parkinson's disease, which causes damage to the portion of the brain responsible for movement, is widely known to be caused by the aggregation of α-synuclein. This...

Researchers have identified an important mechanism of neurodegeneration that may be useful in treating age-related diseases such as Alzheimer’s and dementia [1]. These neurons must die Age-related neurodegenerative diseases, including Parkinson’s and Alzheimer’s, have become more prevalent mostly because of the successes of modern medicine. Today, more people become old enough to fall prey to...

A clinical trial on the effectiveness of niacin supplementation in Parkinson's disease patients has recently been published in Frontiers in Aging Neuroscience. The link between niacin and Parkinson’s disease Niacin is a form of vitamin B3 that is commonly manufactured as a dietary supplement. Patients with Parkinson’s have considerably lower levels of vitamin B3 compared...