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Tag: Fibrosis

Ovary follicle
Scientists have successfully treated ovarian aging in mice with compounds that target fibrosis and promote mitochondrial health [1]. Why do ovaries age faster? Ovarian aging is fascinating because one bodily system completely shuts down while the rest of the body is still in good health. Therefore, studying ovarian aging could provide us with valuable insights...
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month is the paper 'CAR T cells produced in vivo to treat cardiac injury', which looks at how researchers created CAR T cells to target scar...
Chest fibrosis
Scientists have created genetically engineered T cells that target activated cardiac fibroblasts in a transient manner, alleviating symptoms of cardiac injury [1]. HeartThe heart is a four-chambered organ located between our lungs. Blood is pumped by the heart through two loops, one to the lungs, oxygenating the blood, and the other out to the rest...
Kidney fibrosis
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism in adults. KidneyThe kidney's main function is to filter waste products out of the blood and deliver the resulting urine to the bladder. The functional...
Fibrotic liver
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts, cells that are a part of organ fibrosis. It also documents the link between telomere attrition and cellular senescence, two of the hallmarks of aging....
Lung branches
A new review published in the American Journal of Respiratory Cell and Molecular Biology discusses the causes of, and potential treatments for, idiopathic pulmonary fibrosis (IPF). Fibrosis, but not focused on fibroblasts In the lungs, the trachea (airway) breaks out into a tree-like system of nodes. Each branch ends in alveoli, which are responsible for...