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CGI of kidneys
March 25, 2021
A team of researchers led by Dr. Maria Blasco of the Spanish National Cancer Research Center has shown that shorter telomeres make mice more susceptible to kidney fibrosis [1]. The new study not only clearly demonstrates this link but also provides mouse models which can be used to study – and perhaps eventually address –...
Gene segment
October 19, 2020
Researchers have successfully used the CRISPR/Cas9 gene editing tool to destroy Ewing's sarcoma and chronic myeloid leukemia tumor cells by targeting the fusion genes responsible for these tumors [1]. Fusion genes, a feature in many different types of cancer, arise when a mutation fuses two genes together, which typically happens when the DNA sequence between...
August 18, 2020
The Journal Club returns August 25th at 13:00 EDT live on our Facebook page where Dr. Oliver Medvedik will be taking a look at the new study by Dr. Maria Blasco from the CNIO, which shows that telomerase therapy can address fibrosis in normally aged mice and not just mouse models of the disease. Short/dysfunctional...
X-ray of fibrosis
August 12, 2020
Back in January 2018, we reported that, for the first time, researchers had reversed lung fibrosis in mice using a single gene therapy. Today, we want to spotlight a new study that builds on the positive results of the 2018 research, taking us another step closer to telomerase gene therapy in humans to reverse pulmonary...
July 10, 2019
A recently released study from Maria Blasco and her team of researchers at the Spanish National Cancer Research Center (CNIO) shows that the rate of telomere shortening is strongly correlated with the maximum lifespan of animal species. Telomeres Telomeres, which are simply repeating segments of DNA on the ends of our chromosomes, serve two critical...
December 19, 2018
During the Fourth Eurosymposium on Healthy Ageing (EHA), which was held in Brussels, Belgium last November, we had the opportunity to meet Dr. Daniel Muñoz-Espín from the Oncology Department of the University of Cambridge. Dr. Muñoz-Espín received his PhD from the Autonomous University of Madrid, Spain, within the viral DNA replication group at the Centre...