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Tag: β-gal

Muscles in motion
Boosting the expression of the transcription factor NANOG reduces markers of cellular senescence in cultured muscle cells and in live mouse models, according to new research [1]. This holds out the hope that cells could be rejuvenated without reprogramming them to pluripotency, avoiding some of the associated risks such as oncogenicity. However, some of the...
Magnifying glass on DNA
Senescent cells are surprisingly hard to identify, but a recent publication in Tissue and Cell makes the case for using cytoplasmic DNA as a marker of senescence. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
Hand holding drug
A group of scientists from China has successfully created an effective senolytic prodrug that targets the enzyme β-galactosidase [1]. This prodrug, called SSK1, has demonstrated impressive results across various cell types and advantages over some existing senolytics. Cellular senescence is a phenomenon in which cells stop dividing and supporting the tissues of which they are...