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MMTP May 23rd 2016

 

Announcing A New Goal Structure

Hi, everyone! So far, we have raised almost $22,000, which is an amazing effort from the community, and as many people are asking for a more detailed budget, we are going to provide more information and accordingly revise the goal structure of the campaign a bit.

A total of $45,000 is enough funding to run two mouse groups (a control group and a test group) and enough to allow us to begin useful and meaningful research. With two test groups, we will have enough to begin testing combinations of our three senolytic compounds (Quercetin, Dasatinib and Venetoclax) and compare our results against the untreated control group. If we observe an increase in lifespan in the test group versus the control group, we will know that the therapy works.

We are therefore moving the immediate goal to raising $45,000 in order to begin this critical work as soon as possible. Note that as our campaign is Flexible Funding, this change in no way affects how payments work for donations already contributed to the campaign.

The $60,000 goal will now reflect the addition of a positive control group as a stretch goal. A positive control group such as this receives a treatment with a known response so that this positive response can be compared to the unknown response of the treatment. This helps to improve the quality of the data gathered during an experiment, but it is not always included in exploratory studies such as this. We plan to use caloric restriction as our positive control group, which involves a modest reduction of calorie intake and is well documented as predictably increasing lifespan in mice and other animals.

Thank you

The MMTP Team

About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
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