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Tag: Senolytics

January 10, 2020
A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation...
January 07, 2020
Today, we will take a look at the popular supplement fisetin and see how it stacks up as a geroprotector. History of Fisetin Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its...
December 16, 2019
A new study sheds light on the accumulation of senescent cells and suggests that therapies that remove them could be beneficial both immediately and in the long term for human health and longevity. Normally, as cells become damaged beyond repair, exhausted, and no longer able to replicate, they are removed from the body via a...
November 18, 2019
Is the focus on senolytics, drugs that eliminate senescent cells, potentially damaging for longevity? In this interview, Dr. Michael Fossel, who has focused his research on telomeres and the development of telomerase therapy for decades, discusses the potential downsides of senolytics and the promise of telomerase therapy for treating age-related diseases. Senescent cells no longer...
October 30, 2019
Researchers have demonstrated that nanoparticles coated with quercetin molecules can selectively target and eliminate harmful senescent cells. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range...
October 05, 2019
A small-scale human trial by Mayo Clinic researchers has shown for the first time that harmful senescent cells that accumulate with age can be removed from the body by senolytic drugs. This has been demonstrated many times already in mice, but this is the first confirmation that these drugs remove senescent cells in the same...