Help us: Donate
Follow us on:
×

Menu

Back

Tag: Senolytics

Broken bone
A study published in the Journal of Clinical Investigation has reported that senescent cells are largely responsible for slow bone healing in aged animals and that senolytics, which remove these harmful cells, can speed bone regeneration. A brief outline of bone healing BoneBone tissue serves as the primary structural component of our bodies. It protects...
Weightlifting Mouse
A paper published in GeroScience has reported that older mice taking the well-known senolytic combination of dasatinib and quercetin (D+Q) are able to build muscle more like young mice. Senescent cells harm muscle development Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support...
Ginger root
A paper supported by the National Institute on Aging has shown that gingerenone A, a component of ginger extract, is a natural senolytic that is potentially more powerful and less toxic than the combination of dasatinib and quercetin [1]. Ginger and many other plants are widely known for their anti-inflammatory effects. Cellular senescence, in turn,...
Mice and food
New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack α-Klotho have shorter lifespans, cognitive impairment, sarcopenia, vascular dysfunction, osteopenia, cardiac hypertrophy...
Clinical trial
A miniature review of clinical trials targeting aging was published in Frontiers in Aging by Dr. Morten Scheibye-Knudsen and colleagues [1]. This review specifically focuses on interventions that have shown strong clinical evidence that they impact aging. Caloric restriction We have previously discussed the effects of caloric restriction (CR) in reducing immunosenescence, improving DNA repair,...
Cell targeting
An open access study published in iScience has discussed the development of senolytics to target particular genes that are upregulated in cellular senescence. Understanding senescence, cell by cell In our earlier interview with Simon Melov of the Buck Institute, the lead researcher of this paper, Dr. Melov, explained his lab's focus on single-cell sequencing. As...