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Tag: Senolytics

April 07, 2020
Could therapies designed to remove senescent cells, which accumulate with age, potentially be used to treat asthma? The researchers of a recent review certainly believe this could be the case, and there is plenty of reason to think they could be right. Senescent cells and aging As we grow older, increasing amounts of our cells...
February 21, 2020
Researchers have discovered that the powerhouses of our cells, the mitochondria, also play a role in triggering cells to enter senescence, a dormant state in which cells cease to divide and begin to shut down, ready to die. Mitochondria trigger cytoplasmic chromatin and inflammation The new study shows that the mitochondria in each cell communicate...
February 20, 2020
King's College in London, UK has been awarded a grant to investigate the role of senescent cells, which accumulate as we age, in the context of the heart and how using a therapy to remove them influences its ability to recover from injury. What are senescent cells? As you age, increasing numbers of your cells...
January 10, 2020
A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation...
January 07, 2020
Today, we will take a look at the popular supplement fisetin and see how it stacks up as a geroprotector. History of Fisetin Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its...
December 16, 2019
A new study sheds light on the accumulation of senescent cells and suggests that therapies that remove them could be beneficial both immediately and in the long term for human health and longevity. Normally, as cells become damaged beyond repair, exhausted, and no longer able to replicate, they are removed from the body via a...