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Tag: Senolytics

Missing pieces of the brain
January 22, 2021
A new study by a team of researchers, including Dr. Kirkland of Mayo Clinic, shows the effect of whole-body senolytic treatment on the health and function of the brain. This follows up on previous Mayo Clinic research led by Dr. James Kirkland. That experiment treated mice with a combination of the cancer drug dasatinib and...
The robot eye of AI
January 19, 2021
A group of scientists has created a neural network that identifies senescent cells by their morphology and can be used for senolytic drug screening [1]. Image recognition is a showcase triumph of artificial intelligence. While this problem was considered extremely hard to crack in previous decades, algorithms have now exceeded human abilities in multiple cases....
The Sheekey Science Show on fisetin
January 18, 2021
In this video, the Sheekey Science Show explores fisetin, a flavonoid that is found in strawberries and shown to have senolytic effects. This compound, a polyphenol like resveratrol and quercetin, has been shown to somewhat activate SIRT1, which enhances longevity, while eliminating harmful senescent cells in mice, as proven by the reduction of cells that...
2021 on a stethoscope
January 15, 2021
The world of rejuvenation biotechnology is a rapidly changing and ever developing place. As with any disruptive technology, the challenges are significant and include not only the technical aspects of developing these technologies but also the hurdles of societal acceptance of the desirability of longer, healthier lives. While I do not accept the idea proposed...
An elderly woman practicing pilates
January 12, 2021
A new review paper delivers evidence that exercise, a powerful anti-aging tool, may be a natural senolytic [1]. Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known as the senescence-associated...
January 08, 2021
A few years ago, a team at Mayo Clinic led by Dr. James Kirkland treated mice with the cancer drug dasatinib and the popular dietary supplement quercetin, with results suggesting that the combination was able to destroy senescent cells. This combination was part of the first generation of drugs known as senolytics, compounds that encourage...