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Tag: Senolytics

Macaques
In one of the first studies of its kind, the popular senolytic combination, administered systematically for six months, produced several health benefits in these animals. Some effects were augmented by caloric restriction [1]. Coup de grΓ’ce for cells The combination of the drug dasatinib and the flavonoid quercetin, also known as D+Q, is one of...
Bone protection
Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects Zoledronate has already been approved by the FDA for clinical use, as it has been prescribed to prevent bone fractures in vulnerable people for more...
Kelsey Moody
Today, we are speaking to Ichor Life Sciences CEO Dr. Kelsey Moody about the doctoral program that the company operates and how the company is supporting the next generation of scientists. Ichor Life Sciences is a biotechnology company that develops and manufactures new medicines for people around the world. It is focused on creating treatments...
Heartbeat
Researchers have demonstrated that two senolytic drugs might improve how the heart repairs itself by destroying senescent cells [1]. These harmful cells are associated with many age-related diseases, including cardiovascular disease. Zombie cells that refuse to die As we age, our bodies accumulate senescent cells, often referred to as 'zombie' cells. These cells can impair...
AI drug discovery
Research published today in Nature Aging has described a machine learning algorithm that finds senescent cell-removing drugs (senolytics) and compared the algorithm's discoveries to existing compounds. A quest for effective therapeutics What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and cling...
Running mice
Scientists have shown that a popular senolytic combination of dasatinib and quercetin improves glucose tolerance and fasting blood glucose levels in aged mice [1]. The question of metabolism Cellular senescence is one of the hallmarks of aging, and senolytics, drugs that clear away senescent cells, have been shown to ameliorate some aging phenotypes. However, not...