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Tag: Senolytics

Lower back pain
In a recent paper, researchers from McGill University in Canada have investigated how a combination of two senolytics, RG-7112 and o-Vanillin, influences the intervertebral disc cells of back pain patients [1]. Back pain is a widespread issue An overwhelming majority of people, a full 80%, have suffered from back pain at some point in their...
Mouse on hand
In a research paper published in GeroScience, researchers investigated the impact of senolytics on young mice and found some surprising results [1]. Senescent cell removal and other properties Senolytics, when given to older mice, clear senescent cells. Senolytics such as fisetin and quercetin also have anti-inflammatory properties and can be used as chemotherapeutics and senotherapeutics...
Robot detective
Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1]. Searching for new senolytics Senolytics are molecules that destroy senescent cells. Only a small number of such molecules have been identified, and only two have shown efficacy in clinical trials: dasatinib and quercetin in...
Smoking mouse
Researchers publishing in Aging Cell have described how treating the increased senescent cell burden that comes with cigarette smoke exposure can repair some of the damage. Senescent cells and COPD Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which...
Researchers publishing in npj regenerative medicine have found that destroying senescent cells through a well-known senolytic combination gives older killifish back some of their regenerative abilities. Regeneration, for a while Killifish, like starfish and salamanders, are some of the most well-known regenerators of the animal kingdom, able to even regenerate brain tissue [1]. However, these...
Researchers publishing in the Nature journal npj aging have discovered a new peptide that might prevent cells from becoming senescent and possibly youthen human skin. Senolytics and senotherapeutics What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and cling onto life. One...