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Month: January 2023

LSN Cells Ripping
On this episode of Lifespan News, Emmett Short focuses on a recently published paper in which senescent cells tear off portions of their membranes, leaving them attached to other cells. Script Senescent cells and dad jokes are both hallmarks of aging. They’re outdated, irritating and both make you die a little inside. But new research...
Medical funding
VitaDAO, a decentralized organization funding early-stage longevity research and biotech start-ups, has announced the successful closing of a $4.1 million funding round dedicated to financing future longevity projects and furthering its commercialization and licensing strategy for IP-NFT assets. Visit the VitaDAO website to learn how you can get involved. Key contributors to the fundraising round...
Running calico mouse
Scientists have shown that a longevity-associated variant of the BPIFB4 gene protects cardiovascular health, including when introduced by viral vectors [1]. All you need is LAV Among age-related pathologies, cardiovascular disease is the most prolific killer, claiming about 700,000 victims every year in the US alone and as many as 18 million worldwide. However, some...
Heart attack
Research published in Cell Stem Cell has described how previously unmodified animals have been given regenerative abilities akin to those of zebrafish, restoring their heart muscle after injury. A TREE of life This study is introduced with a discussion of gene therapy as a field, noting clinical approval for gene therapies against multiple genetic diseases...
Skin wrinkle
Scientists have demonstrated that extracellular vesicles loaded with mRNA coding for collagen production can be easily produced and delivered into aging fibroblasts in vitro and in vivo, boosting collagen levels and eliminating signs of skin aging in mice [1]. Superior delivery method Finding a good way to deliver molecular cargo into cells is important. Some...
Capillaries
A new publication in Nature Aging has explained a great deal about aging of the neurovascular system, showing where and how the brain's blood supply changes with aging in a mouse model. A branching network of blood vessels In the neurovascular system, arteries lead to arterioles, which then branch off into precapillary sphincters. These lead...