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Tag: Oxidative Stress

Silica dust
A new paper published in Nutrients shows that the well-known NAD+ precursor NMN alleviates lung injury caused by silicate inhalation in wild-type mice. An antioxidant approach to a common problem What is Nicotinamide Mononucleotide? A Summary of NMNNicotinamide mononucleotide (NMN) is a precursor of the coenzyme NAD+, which serves critical functions in our cells. The...
Publishing in Free Radical Biology and Medicine, a team of Chinese researchers has investigated the potential role of autophagy in fighting oxidative stress and potentially staving off age-related macular degeneration (AMD). AMD, oxidative stress, and autophagy AMD comes in two major forms. In the nonexudative (dry) form, material builds up behind the retina, while in...
Killifish
A recent study published in Biogerontology has discovered a potential new aging biomarker and longevity therapeutic target [1]. Isthmin 1 (Ism1) in aging fish  Ism1 is not a well-known protein, but it has been shown to play a role in multiple aspects of biology. It contributes to tumor suppression [2,3], is essential during organ development...
Rat in maze
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause increasing levels of...
A long-eared, long-tailed mouse
Activation of a genetic pathway controlled by the NRF2 gene reduces age-related hearing loss, according to a new study [1]. In the long run, drugs or treatments that target this pathway could help us keep our hearing sharp as we get older. It's getting harder and harder to hear Age-related hearing loss is extremely common,...
A new open-access study from researchers at the Biomedical Research Centre in the United Kingdom shows how two antibiotics and Vitamin C can be combined to suppress cancer stem cells (CSCs) of the breast [1]. While antibiotics are not normally effective against cancer, and Vitamin C is more well-known for its role in supporting the...