Tag: Osteoporosis

In Aging, researchers have published negative results on the long-term use of methylene blue and mitoquinone (MitoQ), two popular antioxidants, to sustain bone health in mice. Oxidative stress and bone health Previous work has found that oxidative stress, which is commonly associated with age-related disease and damage, is related to bone diseases. Substantial amounts of...

In a recent Perspective published in Nature Aging, researchers noted a lack of studies on female-specific physiological factors on aging trajectories. They proposed solutions, including model systems, to address the issue [1]. Most model organisms don't match human sex specificity The use of model organisms, such as worms, fruit flies, and mice, has helped researchers...

Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don't differentiate into bone-building osteoblasts, unlocking a potential new approach to osteoporosis. A matter of cellular fate MSCs are downstream of pluripotent stem cells: they can differentiate into multiple cell types, but not every somatic cell...

Studying a large British cohort, scientists have found that vegetarians have an increased risk of hip fracture compared to regular meat eaters, but pescatarians and occasional meat eaters do not [1]. Diet and brittle bones Hip fracture is one of the injuries most associated with aging. While hip fracture itself is treatable, it can easily...

Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects Zoledronate has already been approved by the FDA for clinical use, as it has been prescribed to prevent bone fractures in vulnerable people for more...

A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts BoneBone tissue serves as the primary structural component of our bodies. It protects our delicate inner organs, plays a key role in whole body calcium, phosphorus, and acid-base homeostasis, and allows movement to...