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Tag: Osteoporosis

June 09, 2020
A group of Japanese scientists has found that advanced glycation end products (AGEs) tend to accumulate in osteoblasts with age, inducing apoptosis via endoplasmic reticulum stress. This mechanism likely contributes to the development of osteoporosis [1]. AGEs and age Advanced glycation end-products, fittingly abbreviated as AGEs, are proteins or lipids that have had sugars attached...
May 26, 2020
Recently, a group of South Korean scientists has analyzed the blood proteome of mice to determine how it changes with age and to identify aging-related proteins that have previously eluded researchers. After identifying several such proteins, the group focused on a specific protein, cadherin-13, that seems to prevent age-related bone loss [1]. The plasma proteome...
September 27, 2018
A recent open-access mouse study published by Xi'an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1]. Study abstract Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia...
September 04, 2017
Osteoporosis is a crippling condition provoked by an imbalance between the creation of new bone tissue and the destruction of the old, which becomes worse as we age.What causes osteoporosis to develop and progress?Osteoporosis is the failure of tissue maintenance in the bones, causing them to become weak and fragile. This increases the risk of...
August 24, 2017
Researchers at the Mayo Clinic have revealed a causal link between senescent cells and bone loss in mice. Senescent cells are one of the hallmarks of aging, and removing them has been proposed as a way to prevent or delay age-related diseases.As your body ages, increasing amounts of your cells become senescent. Senescent cells do...