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Tag: MSCs

Stem Cells for the Knee
A review article published in Stem Cell Research & Therapy has described the ways in which mesenchymal stromal cells (MSCs) are being developed to treat diseases, including age-related diseases. A lack of clinical treatments The reviewers begin their paper by discussing the most common age-related diseases. Immune system problems such as multiple sclerosis [1], brain...
Resarchers publishing in Aging have found that extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (MSCs) reduce inflammatory markers in chondrocytes, which are responsible for building and maintaining human cartilage. An established approach This is far from the first attempt at treating osteoarthritis using stem cells. We have previously reported on a...
Osteoblasts
Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don't differentiate into bone-building osteoblasts, unlocking a potential new approach to osteoporosis. A matter of cellular fate MSCs are downstream of pluripotent stem cells: they can differentiate into multiple cell types, but not every somatic cell...
Guinea pig injection
Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1]. Systemic administration Osteoarthritis, a degenerative joint disease, is one of the most common causes of disability in old age. By limiting the ability to maintain...
Assisted living
A paper published in the journal of the Alzheimer's Association has revealed the results of a Phase 1 clinical trial of stem cells for Alzheimer's disease. Using stem cells for their signals While stem cells, including the mesenchymal stem cells (MSCs) of which Lomecel-B consists, are well-known for their ability to differentiate into other cells,...
Exosomes
A new study in Aging Cell has shown extracellular vesicles from stem cells to extend healthspan and reduce cellular senescence in vitro and in mice. Stem cell exhaustion is a well-studied hallmark of aging that occurs in multiple model organisms and multiple tissue types in humans. This has led to the hypothesis that bolstering these...