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Tag: MSCs

August 25, 2020
A collective of scientists has shown that osteoarthritis can be alleviated by guiding skeletal stem cells towards differentiation into chondrocytes, which are responsible for producing healthy cartilage [1]. Osteoarthritis (OA) is a classic example of an age-related disease. While almost non-existent in younger people, it affects as much as half of the over-65 population worldwide....
August 11, 2020
Researchers have found that CLOCK, a protein that regulates the circadian cycle of our cells, also fights cellular senescence by promoting chromatin stability [1]. Since its very beginning, life on Earth had to adapt to our planet's natural 24-hour rotation cycle. Rising to the challenge, nature invented biological mechanisms called circadian clocks (from the Latin...
April 09, 2020
The COVID-19 pandemic is dominating the news as countries around the world work hard to control the spread of the disease. Social distancing can help "flatten the curve" and prevent the overload of healthcare systems; however, there is a large percentage of people who develop serious complications after getting the virus. The global community is...
March 16, 2020
A study published in Aging and Disease shows the effectiveness of mesenchymal stem cell (MSC) therapy against a deadly immune reaction caused by COVID-19. While scientists all over the world are working on a vaccine that would be effective against the SARS-CoV-2 coronavirus, which is responsible for the COVID-19 pandemic, a group of researchers from...
April 18, 2019
The results of a clinical trial using bone marrow-derived mesenchymal stromal cells (MSCs) to treat late-stage knee osteoarthritis were published recently, and they came back positive. The trial included both phase 1 and 2 and was designed to determine the safety and efficacy of MSC stem cell therapy. A battery of tests During the trial,...
March 14, 2019
Today, we want to point out a new study suggesting that senescent cells in bone marrow cell populations contribute to the decline of the hematopoietic system, particularly the hematopoietic stem and progenitor cells (HSPCs) that live in the bone marrow and produce our blood cells [1]. The hematopoietic system and immunosenescence The hematopoietic system is...