Help us: Donate
Follow us on:



Tag: Microglia

Glia Alzheimer's
September 01, 2020
A group of researchers has proposed three robust transplantation techniques for fighting microglia-related conditions, such as Alzheimer's, and potentially boosting our cognitive abilities [1]. The sentinels of the brain Microglial cells form the backbone of our brain’s immune system. They perform a wide variety of functions, including tracing pathogens, inducing inflammatory reactions, and facilitating the...
Glia Alzheimer's
August 30, 2019
The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer's disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and...
June 28, 2019
A new mouse study highlights the proteins responsible for LC3-associated endocytosis (LANDO), an autophagy process that is involved in degrading β-amyloid, the principal substance associated with Alzheimer's disease. Proteostasis Proteins in the human brain can form misfolded, non-functional, and toxic clumps known as aggregates. Preventing these aggregates from forming, and removing them when they do,...
April 09, 2019
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause of cognitive decline Microglia are immune cells that reside...
December 17, 2018
Researchers have discovered a link between the cellular recycling system known as autophagy and the behavior of microglial immune cells during aging. We have discussed the polarization of macrophages in a number of previous articles, and it has become quite a hot topic among researchers in the last few years. Microglia are tissue-resident macrophages in...
September 20, 2018
Scientists at the Mayo Clinic have implicated senescent cells in yet another age-related pathology—namely, Alzheimer's disease. Led by Dr. Darren Baker, the Mayo Clinic team discovered that clearing senescent microglia and astrocytes in murine brains leads to a much better prognosis for neurodegenerative disease [1]. Study abstract Cellular senescence, which is characterized by an irreversible...