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Tag: Microglia

Mouse Brain Internal
Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences between tissue types To begin this research, the team first performed a gene expression analysis on four different types of murine macrophages: bone marrow-derived macrophages...
Gut Brain Connection
Aging causes changes to the diversity and numbers of bacteria that live in our guts, and it has become a growing area of interest for researchers in recent years. The gut microbiome The gut microbiome is a constantly changing environment populated by vast numbers and types of archaea, eukarya, viruses, and bacteria. It is a...
Glia Alzheimer's
A group of researchers has proposed three robust transplantation techniques for fighting microglia-related conditions, such as Alzheimer's, and potentially boosting our cognitive abilities [1]. The sentinels of the brain Microglial cells form the backbone of our brain’s immune system. They perform a wide variety of functions, including tracing pathogens, inducing inflammatory reactions, and facilitating the...
Glia Alzheimer's
The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer's disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and...
A new mouse study highlights the proteins responsible for LC3-associated endocytosis (LANDO), an autophagy process that is involved in degrading β-amyloid, the principal substance associated with Alzheimer's disease. Proteostasis Proteins in the human brain can form misfolded, non-functional, and toxic clumps known as aggregates. Preventing these aggregates from forming, and removing them when they do,...
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause of cognitive decline Microglia are immune cells that reside...