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Tag: Macrophages

Mouse Brain Internal
Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences between tissue types To begin this research, the team first performed a gene expression analysis on four different types of murine macrophages: bone marrow-derived macrophages...
Back pain
A paper published in Aging has shown that it is possible to treat spinal disc degeneration through altering the epigenetics of macrophages. Macrophages and inflammaging Macrophages are the clean-up crew of the immune system, engulfing and destroying harmful germs, but their polarization is a double-edged sword. On one hand, M1 macrophages serve on the front...
Macrophage
A paper published in Nature Communications reveals that, rather than just summoning fibroblasts, inflammatory macrophages themselves form fibrous tissue that is the basis of scars. The dual role of macrophages Macrophages perform two critical roles in the immune system. After an injury, M1 macrophages spur local inflammation, causing immune cells to converge on the area...
Trojan horse
Researchers from Stanford University and Michigan State University have teamed up to create a nanoparticle that can eat away at the arterial plaques that lead to strokes and heart attacks in a mouse model of atherosclerosis. The team has created a nanoparticle that acts like a Trojan horse, targeting atherosclerotic plaque to reduce its amount...
Clogged artery
A particularly harmful byproduct of oxidized cholesterol appears to be a primary cause of atherosclerosis and a therapeutic target ripe for the taking. A new review takes a look at 7-ketocholesterol and its role in aging and disease. A new review exploring 7-ketocholesterol We recently reported on the launch of Underdog Pharma, a new startup...
Atherosclerosis
A team of researchers from the University of Sheffield in the UK has identified a protein that plays a key role in the development of atherosclerosis, the leading cause of death worldwide. The trouble with Tribbles 1 Researchers have demonstrated for the first time that the protein known as Tribbles 1 (TRIB1) is expressed by...