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Tag: Macrophages

Back pain
May 04, 2020
A paper published in Aging has shown that it is possible to treat spinal disc degeneration through altering the epigenetics of macrophages. Macrophages and inflammaging Macrophages are the clean-up crew of the immune system, engulfing and destroying harmful germs, but their polarization is a double-edged sword. On one hand, M1 macrophages serve on the front...
February 06, 2020
A paper published in Nature Communications reveals that, rather than just summoning fibroblasts, inflammatory macrophages themselves form fibrous tissue that is the basis of scars. The dual role of macrophages Macrophages perform two critical roles in the immune system. After an injury, M1 macrophages spur local inflammation, causing immune cells to converge on the area...
Trojan horse
January 30, 2020
Researchers from Stanford University and Michigan State University have teamed up to create a nanoparticle that can eat away at the arterial plaques that lead to strokes and heart attacks in a mouse model of atherosclerosis. The team has created a nanoparticle that acts like a Trojan horse, targeting atherosclerotic plaque to reduce its amount...
Clogged artery
November 19, 2019
A particularly harmful byproduct of oxidized cholesterol appears to be a primary cause of atherosclerosis and a therapeutic target ripe for the taking. A new review takes a look at 7-ketocholesterol and its role in aging and disease. A new review exploring 7-ketocholesterol We recently reported on the launch of Underdog Pharma, a new startup...
November 11, 2019
A team of researchers from the University of Sheffield in the UK has identified a protein that plays a key role in the development of atherosclerosis, the leading cause of death worldwide. The trouble with Tribbles 1 Researchers have demonstrated for the first time that the protein known as Tribbles 1 (TRIB1) is expressed by...
Glia Alzheimer's
August 30, 2019
The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer's disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and...