March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn't regenerate The researchers note that the liver has a "nearly unlimited regenerative potential" under healthy circumstances. However, when its microenvironment changes due to damage, this...
June 01, 2023
Research published in Aging has shed new light on the relationship between certain liver diseases and cellular senescence. Clogged bile ducts and senescence Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...
April 19, 2023
Chinese scientists have found that the liver removes amyloid-β from circulation in mice, which also decreases its levels in the brain. The age-related impairment of this process might offer a new clue for fighting Alzheimer’s disease [1]. The janitor of the body Despite the flop-laden history of the amyloid-β-centered approach to Alzheimer’s, there is still...
July 25, 2022
A study published in Oxidative Medicine and Cellular Longevity has shown how blueberry extract moderately improves several age-related biomarkers in the livers of aging male rats. Rich in polyphenols In their introduction, the researchers describe polyphenols, a broad category of plant compounds that includes flavonoids. Specifically, blueberries are rich in anthocyanins, a group of polyphenols...
April 29, 2022
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can't we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells: a 'factory reset' that erases cell-specific software and hence...
March 17, 2021
New research in the journal ACS Nano describes a method to improve the efficiency of NMN and metformin in the liver by using a novel nanoparticle delivery method. Nanotechnology in drug delivery Nanotechnology is a broad field that utilizes the unique properties of extraordinarily small materials. In medicine, it has been applied in drug delivery...