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Tag: Fertility

Oocyte
A study conducted at the Institute of Reproductive Medicine in South Korea has shown that the protein expressed by growth-associated gene 6 (GAS6) ameliorates age-related decline in egg cells (oocytes). A protein with many functions Like many other proteins, the GAS6 protein serves multiple functions. It is associated with cellular proliferation, immunity, platelet activation, and...
Fallopian Tube
The entire ovarian niche of mice can now be generated in vitro from stem cells, as a study recently published in Science shows [1]. The researchers then carried out the remarkable feat of fertilizing the generated oocytes and growing healthy, fertile offspring from them. This advance offers an invaluable model for investigating oocyte development and...
X10 Reproductive Clock
On this episode of X10, we talk about why fertility declines with age and what we can do about it. Script How come women can't have children after a certain age, and what can we do about it? Actually, that brings up another question: is it true that the odds get worse each year, or...
Image of an oocyte
According to new research, mutations accumulate in the mitochondrial DNA of egg cells, leading to changes in cellular metabolism, which result in reduced fertility. The study also showed that NMN treatment can restore the metabolic balance in aging mouse oocytes, rescuing fertility. Defective eggs Although malfunctioning of mitochondria and the accumulation of mutations in mitochondrial...
Egg cell
Researchers have discovered that a lack of NAD+ is responsible for mitochondrial dysfunction in egg cells (oocytes), leading to decreased fertility with age. Mitochondria in oocytes Given how much it must divide to create a human being, the oocyte is the largest cell in the human body, and it contains far more mitochondria than any...
Pregnant rat
A new mouse study published in Cell Reports has shown that a metabolic precursor of the coenzyme NAD+ rejuvenates oocytes (egg cells), restoring fertility [1]. The oldest cells In humans, female fertility begins to decline near the end of the third decade of life, long before other markers of aging appear. This age-related decline is...