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Tag: Fertility

Early embryo
Scientists have discovered that immature oocytes maintain their youth by shutting down one of the protein complexes that produce energy in mitochondria [1]. Live slow, stay young Every female is endowed with a finite number of oocytes that form before birth, then reside in the ovaries in a dormant state until maturation and release. Oocytes...
Egg cell
A group of researchers has documented in Aging that Epitalon, a synthetic peptide made of four amino acids, slows the aging of egg cells (oocytes) after ovulation. Aging makes fertilization difficult Oocyte aging is well-known to lead to fertilization deficiencies and a host of other problems that are visible in the cells themselves, including abnormalities...
Unhappy Sperm
A large-cohort population study from Denmark has linked metformin to a 40% increase in the risk of birth defects when taken by fathers during the spermatozoa development period [1]. A drug linked to longevity Metformin is an anti-diabetes drug that drew geroscientists' attention after studies had shown that it reduces all-cause mortality and alleviates diseases...
Uterus
Scientists have found that long-term supplementation with NMN, an NAD+ precursor, dramatically slows reproductive aging in mice by improving mitochondrial function and alleviating senescence [1]. Reproductive aging affects women relatively early in life, but like other types of aging, this one has been considered normal until recently, and no serious attempts have been made to...
Oocyte
A study conducted at the Institute of Reproductive Medicine in South Korea has shown that the protein expressed by growth-associated gene 6 (GAS6) ameliorates age-related decline in egg cells (oocytes). A protein with many functions Like many other proteins, the GAS6 protein serves multiple functions. It is associated with cellular proliferation, immunity, platelet activation, and...
Fallopian Tube
The entire ovarian niche of mice can now be generated in vitro from stem cells, as a study recently published in Science shows [1]. The researchers then carried out the remarkable feat of fertilizing the generated oocytes and growing healthy, fertile offspring from them. This advance offers an invaluable model for investigating oocyte development and...