Tag: DunedinPACE

An accepted manuscript in the Journals of Gerontology has described how a third-generation epigenetic clock is a predictor  of future frailty. Are epigenetic and physiological metrics connected? This paper begins with an examination of two different methods of measuring aging processes. The first is the well-known epigenetic clocks, and this paper lists several, including the...

In a paper published in Geroscience, researchers have developed a metric of systemic inflammation and used it to estimate mortality, finding that it performs better than epigenetic clocks. Evaluating a danger What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read More...

A twin study published in GeroScience has yielded results suggesting that calcium channel blockers, drugs that are commonly used to treat hypertension and other diseases, slow down epigenetic aging and may lengthen healthy lifespan. A wide field The researchers begin this paper by noting that over 400 compounds, as found in the DrugAge database, have...

Researchers publishing in Aging have found a correlation between cognitive decline and measurements of epigenetic aging. Familiar epigenetic clocks Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different kinds of clocks, and...

A preprint published in bioRxiv has demonstrated that the second-generation aging clocks PhenoAge, DunedinPACE, and GrimAge show increased but reversible age acceleration in mice and people exposed to significant stress. What clocks are for Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl...

At Ending Age-Related Diseases 2021, Daniel Belsky discussed the DunedinPACE and DunedinPoAm biomarkers and how biomarkers that measure the pace of aging might prove useful in the development of geroprotectors. Script Thanks everyone for sticking it out for this talk. I'm very pleased to join you and be able to share some of the work...