Tag: Dasatinib

In one of the first studies of its kind, the popular senolytic combination, administered systematically for six months, produced several health benefits in these animals. Some effects were augmented by caloric restriction [1]. Coup de grâce for cells The combination of the drug dasatinib and the flavonoid quercetin, also known as D+Q, is one of...

Researchers have demonstrated that two senolytic drugs might improve how the heart repairs itself by destroying senescent cells [1]. These harmful cells are associated with many age-related diseases, including cardiovascular disease. Zombie cells that refuse to die As we age, our bodies accumulate senescent cells, often referred to as 'zombie' cells. These cells can impair...

Scientists have shown that a popular senolytic combination of dasatinib and quercetin improves glucose tolerance and fasting blood glucose levels in aged mice [1]. The question of metabolism Cellular senescence is one of the hallmarks of aging, and senolytics, drugs that clear away senescent cells, have been shown to ameliorate some aging phenotypes. However, not...

In their publication in eLife Sciences, researchers at Newcastle University in the UK have illustrated how radiation-induced damage can be somewhat ameliorated with senolytics. These researchers focused on navitoclax along with the well-known combination of dasatinib and quercetin. A focus on cancer survivors The researchers begin this paper with a discussion of cancer treatments. They...

A study published in the Journal of Clinical Investigation has reported that senescent cells are largely responsible for slow bone healing in aged animals and that senolytics, which remove these harmful cells, can speed bone regeneration. A brief outline of bone healing BoneBone tissue serves as the primary structural component of our bodies. It protects...

A paper published in GeroScience has reported that older mice taking the well-known senolytic combination of dasatinib and quercetin (D+Q) are able to build muscle more like young mice. Senescent cells harm muscle development Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support...