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Tag: Dasatinib

Vaccination
The journal Nature has published a letter communication regarding a senolytic vaccination study [1]. These letters are typically research studies that the editor chooses to urgently publish due to the importance they hold for the other researchers in the field. They may or may not be peer reviewed before this publication. Background Why we Age:...
Old and Young Mice
A new publication in Aging Cell has found divergent results between the post-injury muscle regeneration of young and old mice treated with senolytics [1]. Senescent cells: Friend or foe for muscle regeneration? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which...
Clinical Trial
A team of researchers, including Dr. James Kirkland of Mayo Clinic, has published a review of the ongoing efforts of researchers to clear senescent cells through senolytics. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
Spinal Disc Degeneration
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were not built to last for as long as humans...
It has been quite a while since the community had fundraised for the MMTP senolytics project; unfortunately, the start of the experiment was delayed due to a number of issues encountered along the way. However, today, we are delighted to announce that the experiment has been approved and has finally launched! The COVID-19 situation To...
human clinical trial
A small-scale human trial by Mayo Clinic researchers has shown for the first time that harmful senescent cells that accumulate with age can be removed from the body by senolytic drugs. This has been demonstrated many times already in mice, but this is the first confirmation that these drugs remove senescent cells in the same...