Tag: Cellular Senescence

Exercise may be able to remove senescent cells only if acute inflammation is allowed to occur, according to a new study published in Aging. Inflammation and senescence Inflammation is known to be a critical part of aging, and its chronic accumulation has been labeled as a hallmark of aging: inflammaging. The SASP, the cocktail of...

Researchers have found that removing senescent cells makes it easier for mice to fight initial infections but harder for them to develop immune memory. Senescence and immunity Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

Researchers have found a new protein target for senescence-related kidney diseases and published their findings in Aging Cell. Kidney disease and fatty acid use Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit...

A study published in Human Nutrition & Metabolism found that prolonged intermittent fasting causes the expression of genes involved in autophagy, the inflammasome, and senescence to change [1]. Fasting your way to better health and longevity? Previous research has linked fasting to delaying the onset of age-related diseases and longevity along with positive outcomes in...

In Aging Cell, researchers have published evidence that downregulating a key aspect of lipid metabolism harms mitochondrial function, but only in cells taken from younger people. Fat regulation at the cellular level Perilipins (PLINs) are proteins that regulate the use of fats (lipids) within cells. This paper focuses on PLIN2, which has previously been investigated...

Researchers publishing in the Journal of Clinical Investigation have developed a new method of screening for compounds, and they found one that appears to directly attack senescent cells involved in lung fibrosis. A disease of senescence What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use...