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Tag: Brain

Capillaries
A new publication in Nature Aging has explained a great deal about aging of the neurovascular system, showing where and how the brain's blood supply changes with aging in a mouse model. A branching network of blood vessels In the neurovascular system, arteries lead to arterioles, which then branch off into precapillary sphincters. These lead...
Obese and healthy mouse
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The researchers introduce this study by discussing human studies. It is well known that obesity is a risk factor for severe metabolic disorders, such as diabetes...
Rats
A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through gene therapy. A well-studied approach IGF-1 is a well-known anti-inflammatory compound, having shown positive effects in human cells [1] and in mouse models [2]. In...
Elderly Japanese couple
Researchers publishing in Nutrients have shown that adding a strain of lactic acid bacteria to the gut flora of older, memory-impaired people partially alleviates their memory problems. A specific anti-inflammatory bacterium The researchers begin their paper by noting that mild cognitive impairment (MCI) is associated with memory loss and is frequent precursor of Alzheimer's disease...
Brain regions
In a new study published in Free Radical Biology and Medicine, researchers have identified a link between mitochondrial function and the vulnerability of specific brain regions to age-associated neurodegeneration [1]. Brain region-specific vulnerability It is well-known that the human brain is heterogeneous in terms of structure and function. The prefrontal cortex is responsible for complex...
Mouse test
Researchers publishing in Nature Communications have detailed how the removal of p16-producing senescent cells leads to improvements in the brains of female mice [1]. Disease-associated microglia and senescence This paper begins with a discussion of disease-associated microglia (DAM) and white matter-associated microglia (WAM). In the aging brain, these exhausted microglia have downregulated genes relating to...