Month: November 2021

Scientists have confirmed yet another positive effect of metformin: its prolonged use by people with diabetes lowers the risk of cognitive impairment and cerebral small vessel disease [1]. A meta-drug? Metformin is one of the top candidate geroprotective (life-prolonging) drugs for several reasons. First, it has been shown to extend lifespan and healthspan in animal...

Longevica, a company focused on the biology of aging, has raised $2.5 million dollars for its platform that it hopes will accelerate life extension research. We have included the full press release below. Longevica to Launch an Open Research Platform to Accelerate the Discovery of Life Extension Mechanisms Company raises $2.5M in funding to support...

A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is associated with sarcopenia, the aging-associated loss of muscle. Why mitochondria control their calcium uptake The calcium ion, Ca2+, is vital in mitochondrial metabolism and interacts...

At Ending Age-Related Diseases 2021, Elena Milova interviewed Dr. Jean Hébert on how the human brain can be restored to youthful function. Script Elena: Greetings to the participants of Ending Age-Related Diseases 2021. This conference brings together thought leaders and researchers working on rejuvenation biotechnology with the goal of extending healthy human life. The supposed...

Researchers have found that hematopoietic stem cells lose function as they grow larger and that rapamycin can alleviate this effect [1]. When cells become obese When it comes to cells, size matters, with stem cells being on the smaller side [2]. Scientists have suspected for quite some time that this wasn’t a coincidence, but the relationship...

Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase inhibitor p21, which is encoded by the Cdkn1a gene, is associated with its own secretome: the p21-associated secretory phenotype (PASP). Similar but not identical to...