Josh Conway

Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal runs out Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly responsible for many...

Research published in Aging has shed new light on the relationship between certain liver diseases and cellular senescence. Clogged bile ducts and senescence Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...

Researchers publishing in Nature Microbiology have determined that the viruses populating the intestines of centenarians are slightly different from those of the merely old. Viruses for bacteria, not people We have written previously about a study showing that centenarians have youthful bacterial gut compositions (enterotypes) similar to those of younger people. This study looks more...

A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and sex differences. A closer look at age-related cancer Over 90% of cancer diagnoses are made in people over a half century old [1]. This is not just because of genomic instability leading to cancerous mutations;...

Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn't work Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause...

Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects Zoledronate has already been approved by the FDA for clinical use, as it has been prescribed to prevent bone fractures in vulnerable people for more...