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September 19, 2022
In the Journal of Inflammation, researchers from Johns Hopkins University have published a detailed review of the relationship between brain inflammation and the principal diseases of dementia. A focus on genetics and environment One out of twenty Americans over 85 have Parkinson's disease [1], and seven out of twenty have Alzheimer's [2]. While genes are...
September 15, 2022
Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis) [1]. Another piece of the puzzle We have recently reported on the effects of mitochondrial fusion and fission...
September 14, 2022
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with hallmarks of aging Duchenne muscular dystrophy is caused by a mutation that gradually destroys the muscles, eventually becoming fatal as it destroys the diaphragm or...
September 08, 2022
Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice. The spread of the SASP Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues...
September 07, 2022
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This paper begins with a discussion of quiescent muscle stem cells, which are held in reserve until injury causes them to form new somatic muscle cells,...
September 05, 2022
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells to revert to a previous epigenetic state, citing previous...
