Josh Conway

A team of researchers has written a paper with a surprising finding: that many of the benefits of caloric restriction and increased NAD+ may be due to their effects on the cilia of hypothalamic neurons. Neuronal cilia have a relationship to overall health Nicotinamide Adenine Dinucleotide (NAD): Benefits and ResearchNicotinamide adenine dinucleotide (NAD) is a...

Researchers publishing in Aging Cell have found that the regulatory protein MTR4 fights DNA damage in the blood vessel lining but decreases with aging. Vulnerable by nature This paper begins by noting the properties, and aging, of vascular endothelial cells (VECs), which line the blood vessels and govern their permeability [1]. As these cells are...

Reviewers publishing in Biology have elucidated SIRT1 functional reserve as an aspect of aging, describing how its depletion is an upstream cause of age-related disorders at the cellular level and explaining why many prospective therapies that increase SIRT1 and NAD+ have not had promising results. Managing a dangerous byproduct Reactive oxygen species (ROS) are necessarily...

In Aging Cell, a team of researchers has described how a little-known gene, ZNF865, has a significant influence on back pain through the regulation of cellular senescence. Lower back pain and senescence are related Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of...

In Aging, researchers have described the differences between the secretions of cells driven senescent through a cancer gene and cells that stopped proliferating due to p16 expression. A difference of kind Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...

Researchers have discovered key biomarkers that are strongly linked to all-cause mortality and identified four measurements with independent predictive power. Biological versus chronological This paper opens with a discussion of a familiar fact for people interested in living longer: one's biological age is not the same as one's chronological age [1]. Biological age gives a...