Josh Conway

In Aging Cell, researchers have described how a strain of Lactobacillus gut bacteria sends chemical signals that enter the bloodstream and decrease fibrosis in the lungs. The gut-lung axis The gut-brain axis, the term for how the intestines and nervous system interact, is well-known to many longevity enthusiasts, and substantial previous research has explained its...

Researchers have explained how a protein found in both yeast and humans facilitates the destruction of the core protein responsible for Parkinson's disease. An aggregate that impairs clearance Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the...

Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. Backbreaking labor is exactly that It has been long-held conventional wisdom that a lifetime of heavy physical labor leads to the early development of arthritis. This has been backed up...

In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells' gene expression will respond to interventions. The need for prediction Simulating biological processes on a computer is an incredibly difficult task. While advanced algorithms such as Google's AlphaFold have revolutionized protein folding,...

Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several clinical trials have found that taking omega-3 PUFAs has benefits for older people. One study found that it reduces the rate of aging according to epigenetic clocks [1], while...

Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts are closely related Cataracts, which cloud the lenses of the eye, are one of the most common sources of age-related vision loss [1]. While they are treatable through surgery...