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September 17, 2020
Researchers have discovered that removing senescent-like neurons alleviates peripheral neuropathy caused by cisplatin, a powerful chemotherapy drug, in mice. Cisplatin As the researchers of this study explain, cisplatin is a chemotherapy drug that works by causing platination in nuclear DNA, which leads to cellular failure, senescence, and death. While this is effective against cancer, this...
September 03, 2020
A research team led by Dr. Brian Kennedy has shown that administration of alpha-ketoglutarate (AKG), a natural metabolite in the citric acid cycle, improves both lifespan and healthspan in middle-aged mice. Modest increase in lifespan For this study, the researchers administered a calcium salt of AKG, CaAKG, to 18-month-old male and female Black 6 mice,...
August 06, 2020
A new study published in Cell Stem Cell has shown how astrocytes, glial cells that perform multiple critical functions in the brain, can become neural stem cells (NSCs) in response to injury. Astrocytes' normal functions The term 'astrocyte', meaning star-shaped cell, refers to a very heterogenous population of cells that perform maintenance, management and constructive...
July 16, 2020
A new perspective published in Cell explains a direct link between genomic instability, one of the primary hallmarks of aging, and age-related diseases. Somatic mutations Mutation is normally explained as the driving force behind evolution, as changes in the germ lines of organisms result in beneficial and harmful mutations to organisms. The organisms with the...
June 24, 2020
In a recent study, researchers from the Buck Institute have shown that cellular senescence, one of the hallmarks of aging, is partially responsible for Alzheimer's disease. Cellular SenescenceAs your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of which they are...
June 11, 2020
Researchers have discovered that a lack of NAD+ is responsible for mitochondrial dysfunction in egg cells (oocytes), leading to decreased fertility with age. Mitochondria in oocytes Given how much it must divide to create a human being, the oocyte is the largest cell in the human body, and it contains far more mitochondria than any...
