Josh Conway

A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is associated with sarcopenia, the aging-associated loss of muscle. Why mitochondria control their calcium uptake The calcium ion, Ca2+, is vital in mitochondrial metabolism and interacts...

Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase inhibitor p21, which is encoded by the Cdkn1a gene, is associated with its own secretome: the p21-associated secretory phenotype (PASP). Similar but not identical to...

A team of researchers publishing in the Nature publication Molecular Psychiatry has described how a newly discovered interaction of amyloid beta (Aβ) is being used in the development of a vaccine for Alzheimer's disease. A specific antibody for truncated Aβ The biochemistry of Alzheimer's is extremely complicated. Aβ is not always one molecule with a...

A preprint published on bioRxiv, whose authors include well-known biogerontologist Vadim Gladyshev, has shown us many interesting details of the effects that heterochronic parabiosis has on aging mice. An old concept studied in new depth Heterochronic parabiosis is the linking of the circulatory systems of young and aged animals. While the researchers note that this...

In a study published in Aging, researchers have found that younger hematopoietic cells can restore older hematopoietic cells through microvesicles, which are facilitators of intercellular communication. Why we Age: Altered Intercellular CommunicationAltered intercellular communication, as described in the Hallmarks of Aging, is the change in signals between cells that can lead to some of the...

A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly...