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Tag: mTOR

Drug combination
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In this paper, the authors argue that to tackle such a multifaced process as aging, it might be beneficial to target different molecular pathways using several...
Pueraria
Publishing in Aging, a team of researchers has discovered how puerarin, an extract of kudzu, ameliorates chronic obstructive pulmonary disorder (COPD) signs in cellular cultures by limiting mitophagy: the consumption of mitochondria by cells. When autophagy isn't a good thing Mitophagy is a subset of autophagy, the consumption of any organelle by a cell. This...
DNA analysis
Scientists have discovered a new mechanism of action of one of geroscience’s favorite molecules, which is related to its anti-cancer effect [1]. Rapamycin – more than a geroprotector Rapamycin needs no introduction in the longevity community. This molecule was discovered in 1972 in a sample of soil from Easter Island (Rapa Nui in the native...
Easter Island
We take a look at rapamycin and why some researchers think it could be useful in combating aging. What is rapamycin? Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. Rapamycin exhibits potent antitumor and immunosuppressive activity. Where is rapamycin found? Rapamycin was first discovered in 1972 in the...
PEARL Rapamycin Campaign
Today is a doubly important day: it marks the final day of the PEARL campaign and it is a celebration of another victory for the life extension community. PEARL smashed its initial fundraising goal and sailed through its two stretch goals, raising just under $183k thanks to the generous support of the community. What is...
Chromatin and histones
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity [1]. This improvement to DNA storage has been observed in both fruit flies and mice in the lab, and the researchers believe that those benefits...