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Tag: mTOR

Glutamine
A new study published in Frontiers of Pharmacology has shown that glutamine deprivation might speed up aging while glutamine supplementation reduces oxidative stress-induced senescence in mice [1]. Glutamine is an amino acid of paramount importance for many cellular functions. It is involved in the synthesis of various crucial molecules, such as the neurotransmitter glutamate and...
Mouse test
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism of Alzheimer's disease in a mouse model [1]. Cleaning up is a big deal The accumulation of "junk", such as misfolded proteins and damaged organelles,...
Drug combination
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In this paper, the authors argue that to tackle such a multifaced process as aging, it might be beneficial to target different molecular pathways using several...
Pueraria
Publishing in Aging, a team of researchers has discovered how puerarin, an extract of kudzu, ameliorates chronic obstructive pulmonary disorder (COPD) signs in cellular cultures by limiting mitophagy: the consumption of mitochondria by cells. When autophagy isn't a good thing Mitophagy is a subset of autophagy, the consumption of any organelle by a cell. This...
DNA analysis
Scientists have discovered a new mechanism of action of one of geroscience’s favorite molecules, which is related to its anti-cancer effect [1]. Rapamycin – more than a geroprotector Rapamycin needs no introduction in the longevity community. This molecule was discovered in 1972 in a sample of soil from Easter Island (Rapa Nui in the native...
Easter Island
We take a look at rapamycin and why some researchers think it could be useful in combating aging. What is rapamycin? Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. Rapamycin exhibits potent antitumor and immunosuppressive activity. Where is rapamycin found? Rapamycin was first discovered in 1972 in the...

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