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Tag: mTOR

January 18, 2021
Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its potential to slow down aging. AKG is a naturally occurring endogenous intermediary metabolite, which means that our own bodies create it, and is part of...
November 24, 2020
Researchers have discovered a chemical pathway that alleviates many harmful consequences of obesity while having little effect on obesity itself [1]. Obesity is bad for your lifespan. This is one of the fundamental truths of longevity science. Obesity drastically increases our susceptibility to cardiovascular diseases, type 2 diabetes, cancer, and other morbidities. It promotes inflammaging,...
December 13, 2019
Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that activate the protein Maf1, repress RNA transcription, and slow genomic instability, which is one of the primary hallmarks of aging. A long chain of causes...
December 04, 2019
If humans ever reach an average lifespan of well over 100 years, what is going to happen? Are we going to be bored with such long lives? "Well," says Prof. Brian Kennedy of the National University of Singapore, "If you ask me: 'Do I want to have cancer at 75? Do I want have Alzheimer’s...
November 18, 2019
ResTORbio announced on Friday 15th that its current phase 3 drug trial for respiratory tract infections did not achieve its primary goal. The drug showed promise in earlier phases of testing, but sadly failed to reduce the incidence of respiratory tract infections in patients aged 65 and above. A setback for RTB101 This news has...
October 21, 2019
The Journal Club returns for a Halloween special, and this time around, Dr. Oliver Medvedik is taking an in-depth look at a recent paper showing that a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system which controls metabolism,...