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Tag: Genomic Instability

Skin aging
A group of researchers successfully alleviated aspects of skin aging by treating skin cells with the NAD precursor nicotinamide [1]. Hard work done by skin leads to its burnout Skin aging might not be lethal, apart from the increased risk of skin cancer, but it's surely conspicuous, frustrating, and emblematic of organismal aging. Being our...
Broken DNA
A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly...
X10 Damaged Genes
On this episode of X10, we talk about the different ways in which DNA is damaged, how our bodies naturally repair it, and how we might be able to help this repair along. Script In our video about genomic instability as a hallmark of aging, we said that DNA repair mechanisms deserve a video of...
Chromatin and histones
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity [1]. This improvement to DNA storage has been observed in both fruit flies and mice in the lab, and the researchers believe that those benefits...
Dividing cells
A team of researchers, including Michael West of AgeX Therapeutics, has authored a review paper that posits a fundamental difference between "immortal" germline cells and "mortal" somatic cells. The two types of cells This review paper, which cites 175 other papers, goes back throughout history, discussing the very earliest scientific theories of aging. It talks...
Centenarian
A new study has shown that people who live for over 105 years typically have a genetic makeup that allows better repair of DNA damage [1]. Looking at the genomes of people who enjoy extreme longevity There has always been lots of interest in what allows some people to live considerably longer than their peers,...