Γ—

Tag: Genomic Instability

Chimeric DNA
According to a newly published paper in Nature Communications, transposable elements impact aging in C.elegans [1]. Transposable elements and aging Transposable elements are often referred to as mobile genetic elements or jumping genes, as these DNA pieces can change their position in the genome. Changing the position of transposable elements can potentially lead to mutations...
Sucralose
Researchers publishing in Journal of Toxicology and Environmental Health, Part B have found that the common sweetener sucralose may contribute to genetic and intestinal damage [1]. Not the only study of this kind This paper begins by stating the fundamental claims that were made prior to the approval of sucralose by the FDA. Those claims...
Bowhead Whale
Scientists have found a possible explanation for bowhead whales’ exceptional lifespan, and it might be translatable to humans [1]. More cells, less cancer With some exceptions, body size is strongly correlated with longevity across species. While this can be explained evolutionarily (larger species have fewer extrinsic threats, which favors slow reproduction and longer lifespan), it...
Abstract DNA
In a new study published in Nature Structural and Molecular Biology, researchers have demonstrated that by manipulating the DREAM protein complex, a major regulator of DNA damage response, it might be possible to alter the number of DNA mutations accumulated with age [1]. Mutations and DREAMs DNA mutations spontaneously occur in both germ-line (reproductive) cells...
In vitro fertilization
Researchers publishing in Aging have found that rapamycin, a molecule thoroughly researched for its effects on metabolism, improves the viability of egg cells (oocytes) grown in vitro. Another approach towards a known problem Decreased fertility in women occurs much more rapidly than other aspects of aging, and advanced maternal age has a substantial impact on...
Bowhead whale
A preprint published in bioRxiv has partially explained the lifespan of the bowhead whale through its duplication of CDKN2C, which regulates how cells divide. Peto's paradox It would be logical for longer-lived animals to be more susceptible to cancer than shorter-lived animals over time, as they have longer to develop the mutations that lead to...