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Tag: Genomic Instability

March 31, 2021
Scientists have alleviated symptoms of the rare premature aging disease ataxia-telangiectasia using NAD+ supplementation in a mouse model [1]. This success deepens our understanding of the role NAD+ plays in aging. The ubiquitous facilitator The coenzyme nicotinamide adenine dinucleotide (NAD+) is one of the foundations of life as we know it, and it may have...
X10 Caloric Restriction Thumbnail
March 15, 2021
In this episode of X10, we discuss the practice of caloric restriction along with its effects, which involve the TOR signaling pathway, epigenetic alterations, and DNA repair.  Sources Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. (2009) Caloric restriction delays...
March 10, 2021
Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be...
March 02, 2021
This is part one of a two-part article where we take a look at NAD+ biology, its history, how it relates to the biology of aging, and the potential for therapeutic interventions via the so-called NAD+ precursors. What is NAD+? Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a...
LifeXtenShow on tangled DNA
January 07, 2021
LifeXtenShow has returned! In this first episode of the new year, Sedeer explains how chromatin is bundled up in the nucleus and how aging turns this bundle into a tangle, leading to genomic instability, epigenetic alterations, and age-related diseases.
Tweezers remove a single gene
January 07, 2021
A gene editing technique published in Nature has proven to be effective in a mouse model of Hutchinson–Gilford progeria syndrome (HGPS). A single error causes tremendous damage HGPS is a well-known disease that causes visible aging and early death in children. In progeria, the lamina that protects the genetic information in the nucleus is greatly...