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Tag: Genomic Instability

X10 Damaged Genes
On this episode of X10, we talk about the different ways in which DNA is damaged, how our bodies naturally repair it, and how we might be able to help this repair along. Script In our video about genomic instability as a hallmark of aging, we said that DNA repair mechanisms deserve a video of...
Chromatin and histones
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity [1]. This improvement to DNA storage has been observed in both fruit flies and mice in the lab, and the researchers believe that those benefits...
Dividing cells
A team of researchers, including Michael West of AgeX Therapeutics, has authored a review paper that posits a fundamental difference between "immortal" germline cells and "mortal" somatic cells. The two types of cells This review paper, which cites 175 other papers, goes back throughout history, discussing the very earliest scientific theories of aging. It talks...
Centenarian
A new study has shown that people who live for over 105 years typically have a genetic makeup that allows better repair of DNA damage [1]. Looking at the genomes of people who enjoy extreme longevity There has always been lots of interest in what allows some people to live considerably longer than their peers,...
Scientists have alleviated symptoms of the rare premature aging disease ataxia-telangiectasia using NAD+ supplementation in a mouse model [1]. This success deepens our understanding of the role NAD+ plays in aging. The ubiquitous facilitator The coenzyme nicotinamide adenine dinucleotide (NAD+) is one of the foundations of life as we know it, and it may have...
X10 Caloric Restriction Thumbnail
In this episode of X10, we discuss the practice of caloric restriction along with its effects, which involve the TOR signaling pathway, epigenetic alterations, and DNA repair.  Sources Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. (2009) Caloric restriction delays...