Tag: genomic instability

New research shows that resveratrol, a chemical found in red wine, contributes to genomic stability by reducing the occurrence of DNA double-strand breaks and prolongs lifespan in genetically modified mice that are prone to carcinogenic mutations [1]. DSBs and genomic instability Genomic instability, one of the hallmarks of aging, is a condition characterized by frequent...

A new study published in Aging shows a clear link between the natural response to genomic damage and cellular senescence, illustrating a principal method by which the effects of a primary hallmark of aging flow downstream. An ATM you don't want to withdraw from When our DNA is damaged, the cell responds with signals, summoning...

Earlier this year, the CEO of Illumina gave a presentation in which he reaffirmed his company's intention to drive the cost of human genome sequencing down to a mere hundred dollars. This has ramifications for every branch of medicine, including rejuvenation biotechnology. Drastically declining costs In 2001, the year when the Human Genome Project was...

A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation...

Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that activate the protein Maf1, repress RNA transcription, and slow genomic instability, which is one of the primary hallmarks of aging. A long chain of causes...

DNA damage, which results in genomic instability, is one of the primary hallmarks of aging. Today, we want to highlight an recent open access review that explores the DNA damage response during aging. The role of DNA damage Some researchers have long suggested that damage to our DNA is a major reason why we age...