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Tag: Genomic Instability

January 07, 2021
LifeXtenShow has returned! In this first episode of the new year, Sedeer explains how chromatin is bundled up in the nucleus and how aging turns this bundle into a tangle, leading to genomic instability, epigenetic alterations, and age-related diseases.
January 07, 2021
A gene editing technique published in Nature has proven to be effective in a mouse model of Hutchinson–Gilford progeria syndrome (HGPS). A single error causes tremendous damage HGPS is a well-known disease that causes visible aging and early death in children. In progeria, the lamina that protects the genetic information in the nucleus is greatly...
January 06, 2021
Research further illuminating the mechanisms of impaired DNA damage repair associated with aging has recently been published in the journal Aging. Genomic InstabilityGenomic instability is the result of gradual damage to DNA in ways that are not naturally repaired. This is a root cause of aging, and it leads to genetic mutations and an increased...
December 17, 2020
New research has shown that a DNA repair gene modulates lifespan in mice [1]. This may serve as a therapeutic avenue or at least open the way towards dissecting the links between DNA damage and senescence. MYSM1 is a gene that removes a molecular mark known as ubiquitin from histones, which are scaffolding proteins that...
October 22, 2020
A new analysis has revealed a core set of genes involved in aging in both humans and mice. Together with a broader set of age-related genes assembled by the study [1], this resource will serve as a launching point for further investigations of the mechanisms behind aging and age-related diseases. The heart of the matter...
September 10, 2020
A short-term caloric restriction diet enhanced a DNA repair process known as non-homologous end joining. These results may partially explain how caloric restriction and similar diets increase lifespan and healthspan in a wide range of organisms. Eat less, live longer Caloric restriction – that is, reduced caloric intake without malnutrition – is one of the...