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Tag: AKG

A picture of the Alpha-ketoglutarate molecule
January 18, 2021
Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its potential to slow down aging. AKG is a naturally occurring endogenous intermediary metabolite, which means that our own bodies create it, and is part of...
The Sheekey Science Show
November 20, 2020
As we reported yesterday on Lifespan.io, the common supplement alpha-ketoglutarate has been shown in a rodent study to combat osteoporosis, the age-related loss of bone tissue caused by an imbalance between bone-building and bone-destroying cells. Today, we present a related video from the Sheekey Science Show, a popular science show that often discusses aging and...
Osteoporosis Hip
November 19, 2020
Research on rodents shows that alpha-ketoglutarate could be an effective way to treat or even prevent osteoporosis [1]. BoneBone tissue serves as the primary structural component of our bodies. It protects our delicate inner organs, plays a key role in whole body calcium, phosphorus, and acid-base homeostasis, and allows movement to occur by giving our...
A picture of the Alpha-ketoglutarate molecule
September 07, 2020
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. History of alpha-ketoglutarate Alpha-ketoglutarate (AKG) was discovered in 1937 by Hans Adolf Krebs and William Arthur Johnson at the...
Dr. Brian Kennedy thumbnail
September 04, 2020
At Ending Age-Related Diseases 2020, Dr. Brian Kennedy of the National University of Singapore discussed the aging population of Singapore, the need for comprehensive healthcare, alpha-ketoglutarate (AKG) and its effects against frailty in mice, ongoing trials of ketoglutarate in humans, spermidine against obesity, the role of biomarkers, and the importance of keeping people well rather...
September 03, 2020
A research team led by Dr. Brian Kennedy has shown that administration of alpha-ketoglutarate (AKG), a natural metabolite in the citric acid cycle, improves both lifespan and healthspan in middle-aged mice. Modest increase in lifespan For this study, the researchers administered a calcium salt of AKG, CaAKG, to 18-month-old male and female Black 6 mice,...