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Tag: AKG

Backwards Clock
A commercially available alpha-ketoglutarate-based supplement has been shown to roll back biological age by 7 years on average in a retrospective human studyย [1]. Live slower, die later Though metformin and rapamycin are getting most of the attention in the longevity field today, alpha-ketoglutarate (AKG) has emerged as another candidate longevity drug. These three molecules have...
AKG may be a useful supplement for slowing down aging.
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. What is alpha-ketoglutarate? AKG is a naturally occurring endogenous intermediary metabolite and part of the Krebs cycle, which means...
A picture of the Alpha-ketoglutarate molecule
Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its potential to slow down aging. AKG is a naturally occurring endogenous intermediary metabolite, which means that our own bodies create it, and is part of...
Osteoporosis Hip
Research on rodents shows that alpha-ketoglutarate could be an effective way to treat or even prevent osteoporosis [1]. BoneBone tissue serves as the primary structural component of our bodies. It protects our delicate inner organs, plays a key role in whole body calcium, phosphorus, and acid-base homeostasis, and allows movement to occur by giving our...
A research team led by Dr. Brian Kennedy has shown that administration of alpha-ketoglutarate (AKG) improves both lifespan and healthspan in middle-aged mice. Modest increase in lifespan from Alpha-Ketoglutarateย  For this study, the researchers administered a calcium salt of AKG, CaAKG, to 18-month-old male and female Black 6 mice, which represents the equivalent of human...