Month: August 2022

In a preprint published in bioRxiv, scientists have shown that long-term supplementation of nicotinamide riboside (NR), a NAD+ precursor, alleviates the progression of age-related hearing loss in a mouse model [1]. An overlooked hearing impairment Globally, age-related hearing loss (ARHL) is the most common sensory deficit of older people. Moreover, it is associated with several...

Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1]. Systemic administration Osteoarthritis, a degenerative joint disease, is one of the most common causes of disability in old age. By limiting the ability to maintain...

On this episode of Lifespan News, Ryan O'Shea discusses how rapamycin and metformin, two well-studied drugs in aging research, can be combined for synergistic effects in mice. Script Rapamycin and metformin are viewed by many as the two most promising anti-aging drugs, but now scientists have found that these drugs can work hand in hand,...

Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm. A new addition to an old paradigm What is Aging? The Nine Reasons We AgeAging is a series of processes that include direct damage, accumulation...

Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases. Atherosclerotic plaques, which consist mostly of cholesterol and fat, can impede blood flow in the artery or burst,...

The Journal Club returns to our Facebook page on Tuesday 30th August at 12:00 Eastern with your host, Dr. Oliver Medvedik. This month, we investigate a paper, Old plasma dilution reduces human biological age: a clinical study, in which Irina Conboy and her team investigated the effects of therapeutic plasma exchange on aging in people....