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Cellular Reprogramming Improves Cognition in Aged Rats
Scientists have shown that prolonged, continuous expression of reprogramming factors counters cognitive decline in old rats and probably decreases their epigenetic age […]
Exploring Senescence in Tendon Function
In Aging Cell, researchers have published new data on the relationship between senescence and the extracellular matrix in the tendons of older people. Easy to injure, hard to […]
A Switch to Whole Food Diets Benefits Elderly People
New research demonstrated how transitioning from a typical Western diet composed of processed foods to a whole-food diet improved cardiometabolic health and body composition and […]
Antinuclear Antibody Shows Promise Against Cancer
Scientists have developed a conjugate of a drug and a nucleus-targeting antibody that can attack multiple types of cancer cells without targeting a particular antigen [1]. The anti-nuclear missile Antinuclear antibodies (ANA) are usually associated with autoimmune diseases, […]
Exploring How Stiffness Promotes Osteoarthritis
In iScience, researchers have explained how physical mechanics can alter mitochondrial function in a way that leads to osteoarthritis. When simple physics […]
Late-Life Treatment Increases Mouse Lifespan by 25%
A new mouse study has found that both germline knockout and late-life inhibition of the pro-inflammatory cytokine IL-11 lead to comparable and powerful healthspan and lifespan extension [1]. The inflammatory message As […]
Discovering Why an Inflammatory Compound Inhibits Cancer
In Aging Cell, researchers have published their findings into why the inflammatory factor IL-6 inhibits cancerous tumors when generated inside the cell. IL-6 affects both senescence and cancer proliferation One of […]
Probiotics Have Positive Cognitive Effects in Trial
A clinical trial has found that consuming a multi-species probiotic formulation positively impacts mental well-being and improves cognitive functions [1]. Gut-brain crosstalk The gut microbiome is a […]
Longevity Biotech Fellowship: Road To A Post-Aging Society
The Longevity Biotech Fellowship is one of the most interesting longevity-related initiatives in the last couple of years. Co-founded by Mark Hamalainen and Nathan Cheng, both well-known figures in the longevity field, […]
Mixed Results in Probiotic Trial Against Inflammaging
Researchers publishing in Probiotics and Antimicrobial Proteins have published the results of a clinical trial on the effects of a probiotic on inflammaging in older people. The gut and systemic inflammation The researchers begin this paper discussing […]
Why We Age: Epigenetic Alterations
Think of DNA as the master recipe book for your body, with every cell containing a nucleus also containing a copy of this book. Interestingly, not all cells use every recipe and the same cell can change which recipes it […]
Modified Natural Killer Cells Effective Against Liver Cancer
By making NK cells insensitive to tumor-secreted TGF-β, scientists have improved their efficacy against this deadly hepatocellular carcinoma (HCC) [1]. Liver cancer and TGF-β Cancer cells, which are supposed to be vulnerable to the […]
Sex Differences in the Blood-Brain Barrier and Alzheimer’s
Researchers have found that men and women have significant differences in how their brains’ blood vessels change in Alzheimer’s disease. The collapse of the blood-brain barrier This research begins with a discussion […]
Precision Nutrition Improves Life Quality for Older People
Researchers compared general nutritional advice to individualized nutritional advice in addition to an app that encourages its users to follow a diet. Elderly overweight and […]
Scientists Eliminate Cancer Using Evolutionary Principles
A new study describes a method of genetically modifying a fraction of tumor cells, programming them to self-destruct and take therapy-resistant cells with them [1]. Resisting the resistance Advanced solid tumors remain the main challenge […]
A Molecular Reason Why Exercise Fights Senescence
Researchers publishing in Aging have found a molecule linking exercise to the inhibition of cellular senescence, one of the hallmarks of aging. Exercise against […]
Novel Drug Suppresses Metastatic Cancer in Mice
Scientists have found a small molecule that turns an anti-apoptotic protein into a pro-apoptotic one, protecting against deadly metastases in a mouse model of human triple-negative breast cancer and, potentially, in other cancers [1]. […]
A New Target for Chronic Lung Diseases
Revealing their findings in Aging Cell, researchers have found a new biochemical target for chronic obstructive pulmonary disease (COPD). Smoking is only one cause […]
Recurrent Pregnancy Loss Associated with Increased Dementia
A recent paper in the European Journal of Epidemiology reported that recurrent miscarriage and stillbirths are associated with the occurrence of dementia, but there was insufficient evidence to establish such a connection between infertility and dementia [1]. […]
Longevity and DeSci Recap – June 2024
This summer season is red hot in the world of longevity. Packed with interesting events, investments and new research proposals, the future of longevity is becoming today’s reality. Join us as we run through the […]
Four Days of Longevity in Dublin: Conference Highlights
The annual Longevity Summit Dublin happened this June, and we are bringing you the highlights. Initiated by Aubrey de Grey and Martin O’Dea in 2022, this conference has earned a reputation […]
Nicotinamide Riboside Improves Walking in Clinical Trial
Researchers publishing in Nature Communications have found that nicotinamide riboside (NR) improves walking distance for people who have peripheral artery disease (PAD) in the legs. When the arms and legs don’t get enough […]
Rejuvenation Roundup June 2024
Puzzle pieces are being fit together and connections are being made in understanding the massive number of biological changes that make […]
Developing a New Aging Clock for Medical Professionals
In Nature Aging, researchers have published the creation of a new clock that uses multiple metrics to evaluate biological aging. What’s worth measuring? Multiple metrics have been used […]
70 Is Indeed the New 60, Study Suggests
Scientists have found that older people currently retain more youthful abilities than people who were the same age did in previous decades [1]. How miserable are […]
Encouraging Mitochondrial Maintenance to Fight Senescence
Researchers have published a method of rescuing cells from damaged mitochondria and cellular senescence, potentially alleviating major aspects of aging. Bad mitochondria must be consumed A core part of autophagy involves selective autophagy […]
Blueberry Polyphenol May Relieve Plastic-Caused Sperm Damage
A recent paper has investigated the impact of polystyrene nanoplastics on the molecular processes of male reproductive tissues in mice [1]. Health risks of micro- and nanoplastics Microplastic and nanoplastic contamination is a worldwide public health concern for a good […]
Study Links Stress to Mitochondrial Dysfunction in the Brain
For the first time, scientists have shown that the abundance of proteins needed for mitochondrial energy production in human brains is linked to perceived psychosocial experiences [1]. Picking the brains Negative psychosocial experiences […]
New Drug Restores Telomerase, Improves Cognition in Mice
Scientists have identified a small molecule that upregulates telomerase reverse transcriptase (TERT) in multiple tissues, improving health and cognition in old mice. Telomere attrition and health The enzyme telomerase can prevent telomere attrition from happening by extending the […]
Walking Reduces Risk of Low Back Pain Recurrence
Publishing in The Lancet, scientists have shown that simple walking can have significant effects on the recurrence of back pain and disability metrics. […]
