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Tag: Sarcopenia

Elderly muscle
Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal runs out Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly responsible for many...
Treadmill mouse
A paper published in Aging has detailed how gene therapy has been used to treat sarcopenia in wild-type mice, and the results are positive. A lack of effective treatments As expected with papers of this kind, the researchers begin by discussing frailty and sarcopenia, the age-related loss of muscle tissue that is associated with decreased...
Elderly lifting
Research published in Nature Metabolism has described PCYT2, an enzyme essential for muscle function, and how it declines with aging. A necessary lipid synthesizer in muscle Human beings need PCYT2 as part of the Kennedy pathway to synthesize two critical components of the phosopholipid membrane that surrounds cells [1]. People with genetic deficiencies of PCYT2...
Protein muscle
Researchers publishing in Age and Ageing have found that, rather than being protective, an increase in dietary protein is associated with an increased chance of sarcopenia. Sarcopenia is a well-known disorder that occurs with aging. People with sarcopenia lack adequate muscular function, leading to frailty, a higher risk of falls, and a functional decline in...
Immunis
Intending to treat sarcopenia, the private biotechnology company Immunis has begun a human clinical trial of a stem cell secretome product that affects the immune system. The company's full press release is included here. Immunis, Inc., a private biotech company developing an innovative treatment for age and disease-related immune decline, announces its first-in-human injection of...
Heart cells
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose the nucleus in the lamina, the cellular envelope that contains and protects DNA. In progeria, a mutation of the gene that codes for the Lamin...