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Tag: Sarcopenia

muscle and bone
In a new study published in Bone Research, Japanese researchers established a novel drug screening system and identified a promising compound to treat age-associated muscle and bone frailty [1]. Musculoskeletal system Muscle health and bone health are tightly interconnected. Various muscular dystrophies are a great example: disease-caused muscle wasting leads to skeletal deformities, which prompts...
Mouse running
A team of researchers publishing through Multidisciplinary Digital Publishing Institute has described an association between the peptide ghrelin and skeletal muscle aging in mice [1]. An appetite stimulant with potential side effects Ghrelin is a peptide containing 28 amino acids. Its main function is to stimulate the appetite through receptors in the hypothalamus [2], but...
Muscle DNA
In a new study published in Journal of Nanobiotechnology, researchers prevented muscle atrophy both in vitro and in vivo by delivering a CRISPR-Cas9 gene editing system packaged in engineered extracellular vesicles [1]. When just using it doesn’t quite cut it Aging is accompanied by the loss of muscle mass, also known as sarcopenia, which deteriorates...
Strong mouse
In their publication in Stem Cell Research & Therapy, a team of researchers has shown how effective mesenchymal stromal cells (MSCs) are in a mouse model. Multipotent cells with multiple uses As multipotent stem cells, MSCs can differentiate into several different cell types, including fat cells, neurons, and bone cells [1]. The researchers point to...
Many lab mice
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in muscle tissue. The role of mTORC1 Mammalian target of rapamycin complex 1 (mTORC1) is a well-known component of fundamental nutrient sensing pathways whose dysregulation is...
Skeletal Muscle
A study published in the Journal of the American Medical Association has examined the dosage and safety of a urolithin A supplement [1]. This study also examined urolithin A's effect on muscle endurance and specific health biomarkers. A randomized, controlled clinical trial  This study is a follow-up to prior work done by the Amazentis company,...

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