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Tag: Rapamycin

Needles in haystack
In a recent paper published in International Journal of Medical Sciences, researchers have described how they used artificial intelligence and machine learning tools to find mTOR-inhibiting molecules [1]. mTOR is a common target for lifespan extension interventions The mechanistic target of rapamycin (mTOR) is a well-known molecule in the rejuvenation world. Previous studies have demonstrated...
White mouse
Scientists have concluded that rapamycin treatment started in early mid-life can prevent age-related blood flow impairment in the hindlimbs of wild-type, atherosclerotic, and Alzheimer's model mice [1]. PAD and aging Peripheral artery disease (PAD) is defined as reduced blood flow to the lower limbs. Age is a major risk factor for PAD, as the disease...
Mouse eating
In a new study published in Aging Cell, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, reverse aging in a population of intestinal stem cells [1]. The aging intestine Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various...
Infectious disease
A meta-analysis published in GeroScience has shown that the well-studied drug rapamycin has positive effects on infection in mice, but dietary restriction seems to worsen the problem. Aging, immunity, and interventions This paper begins with the well-known information that aging impairs the immune system, harming its effectiveness against infectious diseases [1] while causing systemic inflammation...
In vitro fertilization
Researchers publishing in Aging have found that rapamycin, a molecule thoroughly researched for its effects on metabolism, improves the viability of egg cells (oocytes) grown in vitro. Another approach towards a known problem Decreased fertility in women occurs much more rapidly than other aspects of aging, and advanced maternal age has a substantial impact on...
Multiple drugs
In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1]. Anti-aging agent testing Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity...