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Tag: Rapamycin

Drug combination
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In this paper, the authors argue that to tackle such a multifaced process as aging, it might be beneficial to target different molecular pathways using several...
Richard Miller
Richard A. Miller is a Professor of Pathology at the University of Michigan and the Director of Michigan's Paul F. Glenn Center for Biology of Aging Research. He is also a driving force behind the ITP, the Interventions Testing Program, created in the early 2000s to study the effect of various drugs on lifespan in...
Fruit flies
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong treatment, including lifespan extension in flies [1]. Rapamycin is considered one of the most promising geroprotective drugs. It belongs to a handful of molecules that...
Many lab mice
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in muscle tissue. The role of mTORC1 Mammalian target of rapamycin complex 1 (mTORC1) is a well-known component of fundamental nutrient sensing pathways whose dysregulation is...
Running Mice
A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of mice. Rapamycin before and after weaning In this placebo-controlled experiment, the researchers selected the UMHET3 strain of mice, as it is a crossbreed that does...
Dividing stem cells
Researchers have found that hematopoietic stem cells lose function as they grow larger and that rapamycin can alleviate this effect [1]. When cells become obese When it comes to cells, size matters, with stem cells being on the smaller side [2]. Scientists have suspected for quite some time that this wasn’t a coincidence, but the relationship...