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Tag: IL-6

Manhattan plot
Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. What is Inflammaging? Chronic Inflammation and AgingThe aging process is accompanied by a chronic, smouldering background of inflammation that researchers call “inflammaging”.Read More An extremely broad study with a wide variety of genes Pulling genomic...
Aging DNA
In a new study, mice transduced with a longevity-associated variant (LAV) of the BPIFB4 gene showed less immunosenescence and healthier vasculature [1]. The importance of having good genes Longevity-associated alleles prove that aging does not affect everyone equally. On average, centenarians and supercentenarians are more protected from age-related diseases than other people, and this protection...
Old man eye
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin is a well-known heat shock protein, a family of proteins that is used in temperature regulation. This protein has been previously demonstrated by this research...
Spinal Injury
A team of researchers publishing in Aging have shown that resveratrol reduces inflammation and partially restores function in a rat model of spinal injury. In line with previous research This is far from the first study that aimed to use approaches associated with aging research in order to spur regeneration. For example, we have previously...
Storm
Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause of the cytokine storm, an immune overreaction that is more common in the elderly and is known to cause severe dysfunction and even death when...
Bad news
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, can lead to cellular senescence. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead,...