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Tag: Epigenetics

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March 08, 2021
Today, we chronicle the progress of partial cellular reprogramming and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing epigenetic alterations, one of the proposed reasons we age. For those of you new to the subject of epigenetic alterations you can learn more by...
LifeXtenShow on the tones of DNA
February 04, 2021
In this episode of X10, Nicola explains methylation in the context of language tones, showing how DNA methylation leads to DNA interpretations being slightly different between cells. He also introduces the idea of epigenetic clocks and discusses how gene expression, epigenetic alterations, and methylation are related. HELP SPREAD THE WORD Please connect with us on...
clockwork suit
December 14, 2020
These days, it seems like you cannot go for a walk without tripping over another aging clock, and today is no exception. DeepMAge, a DNA methylation aging clock developed using deep learning, has recently been created by the Hong Kong-based company Deep Longevity. There are two common ways to measure age: biological and chronological. The...
Journal Club
December 10, 2020
The journal club is back for December and we will be discussing the new Sinclair lab paper where researchers have successfully rejuvenated the eyes of aged mice using cellular reprogramming. As some additional background, we recently covered the paper in an article on the news outlet which you can find here. Join us December 22nd...
Steve Horvath at Ending Age-Related Diseases 2020
December 01, 2020
Dr. Steve Horvath is very well known in the field for his groundbreaking work on epigenetic clocks, which use one of the hallmarks of aging, epigenetic alterations, in order to calculate biological age. In his talk at Ending Age-Related Diseases 2020, he discussed how such clocks can be used to evaluate the effectiveness of rejuvenation...
Death clock
November 26, 2020
A new study published in the Journals of Gerontology has shown that the epigenetic clock GrimAge is a strong predictor of the effects of aging, particularly all-cause mortality: the likelihood of dying from any cause. Did previous clocks use the wrong target? As the researchers explain, the first-generation epigenetic clocks of Drs. Horvath (who contributed...