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Tag: DNA Methylation

Mice playing
A study published in Nature Communications has shown that an environment rich in stimuli changes the epigenetics of the mouse hippocampus, making the brains of aged mice more like those of young mice [1]. What is an enriched environment? For mice, enriched environments (ENRs) are "large cages equipped with frequently rearranged toys, providing physical, cognitive,...
Magnifying glass on cancer
Biotech company GRAIL made history earlier this month when it introduced the first commercially available multi-cancer blood test. The test is based on analyzing tumor DNA in circulation and could be a game-changer in the field of cancer diagnostics, especially if the company continues to improve it. Discovering cancer early Medicine has made great strides...
Elderly twins
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors - smoking, drinking, physical activity, and diet - affect biological age according to two biological age clocks. Their findings were a mixed bag, but they found evidence for eating lots of fruits and vegetables [1]. DNA methylation clocks With age, our...
Reset button
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and other age-related diseases. One of the proposed reasons we...
Epigenetic wrapping
A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known technology for editing the genome, but its potential for epigenetic editing had never been previously explored. With a directed CRISPR memory writer able to methylate...
binary clock image
Scientists have devised a transcriptome-based aging clock that allows for precise measurement of biological age in C. elegans worms and shows promising results in humans as well [1]. The purpose of aging clocks One of the central questions of longevity research is how to measure biological age. If a pathology, genetic difference, lifestyle choice, or...