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Tag: DNA Methylation

Stressful stimuli
Researchers publishing in Aging have found that stresses, both biological and in daily life, harm one of our fundamental abilities to correctly process what's going on around us. What is sensory gating? Sensory gating is the brain's ability to filter out irrelevant stimuli after the first time it experiences them. It reflects our ability to...
Mice playing
A study published in Nature Communications has shown that an environment rich in stimuli changes the epigenetics of the mouse hippocampus, making the brains of aged mice more like those of young mice [1]. What is an enriched environment? For mice, enriched environments (ENRs) are "large cages equipped with frequently rearranged toys, providing physical, cognitive,...
Magnifying glass on cancer
Biotech company GRAIL made history earlier this month when it introduced the first commercially available multi-cancer blood test. The test is based on analyzing tumor DNA in circulation and could be a game-changer in the field of cancer diagnostics, especially if the company continues to improve it. Discovering cancer early Medicine has made great strides...
Elderly twins
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors - smoking, drinking, physical activity, and diet - affect biological age according to two biological age clocks. Their findings were a mixed bag, but they found evidence for eating lots of fruits and vegetables [1]. DNA methylation clocks With age, our...
Reset button
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and other age-related diseases. One of the proposed reasons we...
Epigenetic wrapping
A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known technology for editing the genome, but its potential for epigenetic editing had never been previously explored. With a directed CRISPR memory writer able to methylate...